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Bioscience & Health Programs & Projects

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Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers
Last Updated Date: 03/13/2013

Proteins are of significant interest as potential indicators (biomarkers) of health or disease. Clinical methods employed to measure these … more

Metallomics: A Multidisciplinary Approach for the Qualitative and Quantitative Determination of Proteins and Metalloproteins Used as Health and Disease Markers
Last Updated Date: 03/13/2013

As healthcare shifts from management of disease to management of health, there will be a necessary shift toward development of quantitative health … more

Development of Methods for Measurement of Vitamin D in Foods, Fortified Foods, and Dietary Supplements
Last Updated Date: 03/13/2013

Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and … more

Development of SRM 955c Lead in Caprine Blood
Last Updated Date: 03/13/2013

Environmental and occupational exposure to toxic metals is assessed through whole blood analysis. Due to advances in measurement technology, … more

Understanding Protein Solution Phase Behavior via Coarse-Grained Modeling
Last Updated Date: 02/14/2013

Much of our knowledge of protein folding comes from experiments on polypeptides in dilute solutions or from theoretical models of isolated … more

Nanotechnology for Sustainable Water and Energy
Last Updated Date: 02/06/2013

Objective We synthesize and characterize catalytic nanoparticles and nanoparticle-enhanced membranes for more efficient water treatment and … more

Medical Device Reliability
Last Updated Date: 01/30/2013

The growing sophistication of electronic medical devices results in two broad benefits for both individuals and society: improved survivability in … more

Development of a Collagen Fibril Reference Material for Reproducible Cell Response
Last Updated Date: 01/11/2013

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which … more

Instrumented Bioreactors
Last Updated Date: 12/17/2012

Our goal is to develop novel bioreactors that combine mechanical stimulation with integrated sensing to enable real-time optimization of the … more

Traceability in Molecular Spectrophotometry
Last Updated Date: 11/20/2012

Standard Reference Materials (SRMs) and NIST Traceable Reference Materials (NTRMs) for UV/visible/NIR spectrophotometry are certified transfer … more

Photodetector Analysis for Biological Agent Detection
Last Updated Date: 11/16/2012

Photomultiplier tube (PMT) analysis with respect to PMT sensitivity and long-term stability using synchrotron radiation.

Nanoparticle Characterization
Last Updated Date: 11/16/2012

The Chemical Sciences Division is helping to support nanotechnology research being conducted throughout NIST by developing and applying methods … more

Micronutrients Measurement Quality Assurance Program
Last Updated Date: 11/16/2012

The Micronutrients Measurement Quality Assurance Program , coordinated by the Chemical Sciences Division, supports measurement technology for … more

Surface Characterization of Conjugated Gold Nanoparticles
Last Updated Date: 11/16/2012

This work examines the surface chemistry of conjugated gold nanoparticles, where the molecular modifiers are linked to the gold NP via a … more

Renewal of NIST Benchmark SRMs for Accurate Determinations of Trace Elements in Serum and Liver Tissues
Last Updated Date: 11/15/2012

The Centers for Disease Control and Prevention (CDC) collects data on elemental composition of human body fluids and tissues as part of major … more

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