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Chemistry Programs & Projects

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Next-Generation Metrology for Drug Delivery Systems
Last Updated Date: 10/02/2012

A critical metrology issue for pharmaceutical industries is the application of analytical techniques to the characterization of drug delivery … more

Rapid Isotopic Screening
Last Updated Date: 10/02/2012

We have exploited the built-in functionality of a secondary ion mass spectrometer to provide the capability to screen the enrichment levels of a … more

Trace Narcotics Detection
Last Updated Date: 10/02/2012

A large suite of illicit drug samples were analyzed using IMS to evaluate the selectivity and sensitivity of the technique. The sample suite … more

Molecular Orbital Structure of Energetic Nitrogen Compounds from X-Ray Emission Spectroscopy
Last Updated Date: 10/02/2012

When chemical compounds of low-Z elements are excited by x-rays, the ionized core states are filled from the valence band. The molecular orbital … more

Trophic Transfer of Nanoparticles in a Simplified Invertebrate Food Web
Last Updated Date: 10/02/2012

We demonstrated that carboxylated and biotinylated quantum dots (QDs) can be transferred to higher trophic organisms (rotifers) through dietary … more

Milli X-ray Fluorescence X-ray Spectrum Imaging Technique Development
Last Updated Date: 10/02/2012

Significant improvements were made in the area of technique development for Eagle III mXRF since its initial installation in 2007. The diverse … more

Mitigation of Systematic Errors in EFTEM Spectral Imaging via Median Filtering
Last Updated Date: 10/02/2012

A method has been developed for the removal from CCD images of point blemishes (PBs) ubiquitous in the acquisition of energy-filtered transmission … more

Chemistry in Analytical Microscopy Group
Last Updated Date: 10/02/2012

Chemistry is the science concerned with the composition, structure, and properties of matter, as well as the changes it undergoes during chemical … more

Inkjet Gravimetry
Last Updated Date: 10/02/2012

Gravimetric and optical methods were developed to assure quantitative deposition of compounds from nano-dispense devices onto the surfaces of … more

Evaluation of the Extent of Electron Scattering in a Low Vacuum Scanning Electron Microscope
Last Updated Date: 10/02/2012

Low vacuum scanning electron microscopes utilize gas molecules in the specimen chamber to neutralize the specimen charging from the impinging … more

DTSA-II Reinvention of a Classic
Last Updated Date: 10/02/2012

The original NBS/NIH DTSA (Desktop Spectrum Analyzer) software was widely used in the x-ray microanalysis research community. The combination of … more

Depth Profiling of Drug Eluting Stent Coatings with Cluster SIMS
Last Updated Date: 10/02/2012

There is much excitement in the cardiology community about drug eluting stents (DES), a promising new treatment for coronary artery disease. A … more

Atomic Scale Imaging of Nanoscale Structures with Elemental Sensitivity in the NIST Titan 80-300
Last Updated Date: 10/02/2012

The characterization of CdSe/ZnS quantum dot structures has been carried out with compositionally sensitive imaging techniques utilizing the … more

Coupling Nanowire Chemisresistors with MEMS Microhotplate Gas Sensing Platforms
Last Updated Date: 10/02/2012

Recent advances in nanotechnology have yielded materials and structures that offer great potential for improving the sensitivity, selectivity, … more

Analysis of Copper Incorporation Into Zinc Oxide Nanowires
Last Updated Date: 10/02/2012

ZnO nanowires (NWs) are grown on bulk copper by chemical vapor deposition. Photoluminescence (PL) microscopy revealed band gap emission at 380 nm … more

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