Towards DNA Sequencing with Solid-State Nanopores

Human body is an amazing ensemble of trillions of cells. It is even more remarkable that all the information necessary to build it is contained within a single molecule — DNA. This information is encoded in the precise order of nucleotides within the molecule. Nanopore sequencing is the DNA sequencing method in which the order of nucleotides is determined while the molecule moves through a nanoscale opening (pore) in biological or solid-state membranes. Although synthetic solid-state nanopores have various advantages over their biological counterparts, a number of challenges have to be addressed in order to make DNA sequencing with solid-state nanopores possible. In my talk I will present computational studies of a number of solid-state nanopores systems designed to address these challenges.

For further information please contact Michael Zwolak, 301-975-4258, michael.zwolak [at] nist.gov (michael[dot]zwolak[at]nist[dot]gov)