Welcome to the NIST Clinical DNA Information Resource

CDIR is a reservoir of information for clinical DNA Standard Reference Materials (SRMs) including presentations, publications, and links to NIST SRM certificates. Also included are webpages that summarize the purpose for the reference material and the methods used for certification. CMV project pages contain additional information that researchers and clinicians may find useful. Future materials have progress updates.

General Information

• Publications/Presentations
• RJ Haynes, et. al. "Standard Reference Material 2366 for Measurement of Human Cytomegalovirus DNA." The Journal of Molecular Diagnostics, Vol. 15, No. 2, March 2013 [pdf]
  
• Marcia J. Holden et. al. "Molecular diagnostics: harmonization through reference materials,documentary standards and proficiency testing." Expert Rev. Mol. Diagn. 11(7), 741–755 (2011) [pdf]
  
  

Standard Reference Materials (SRMs)

 

Clinical DNA SRMs

• Cytomegalovirus for DNA Measurements (SRM 2366)
  
  • SRM Page (view Certificate or purchase SRM 2366)
  • CMV project pages
• Huntington's Disease (SRM 2393)
  
  • SRM Page (view Certificate or purchase SRM 2393)
  • Huntington's Disease project page
    

 

SRMs in Progress

• BK virus
  
  • BK virus project page
    
  
  

Other DNA Based SRMs

• Human DNA Quantitation Standard (SRM 2372)
  
  • SRM Page (view Certificate or purchase SRM 2372)

• Mitochondrial DNA Sequencing (SRM 2392)
  
  • SRM Page (view Certificate or purchase SRM 2392)

• Mitochondrial DNA Sequencing (Human HL-60 DNA) (SRM 2392-I)
  
  • SRM Page (view Certificate or purchase SRM 2392-I)

• PCR-Based DNA Profiling (SRM 2391c)
  
  • View Certificate or purchase SRM 2391c

• Human Y-Chromosome DNA Profiling (SRM 2395)
  
  • View Certificate or purchase SRM 2395

Additional Materials Under Consideration

• Epstein-Barr virus