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Organic Chemical Measurement Science Group

Welcome

The Organic Chemical Metrology Group is responsible for developing, critically evaluating, and applying liquid chromatographic, gas chromatographic, and mass spectrometric techniques for the identification and measurement of organic species in a variety of matrices. Efforts are directed toward applications in clinical chemistry, environmental chemistry, food and nutrition, and forensics and homeland security, and include sample types such as tissues and biological fluids, air particulate matter and sediments, foods and dietary supplements, energetic materials, and pure substances (i.e., reference standards). Measurement services are provided through the development of definitive and reference methods, Standard Reference Materials (SRMs), and quality assurance programs.

Programs/Projects

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum—Hormones are chemical messengers that regulate many life functions, and deviations from normal levels can indicate serious health problems. Measurement of levels of steroid and/or thyroid hormones …

Interlaboratory Comparison Exercises for Organic Contaminants and Trace Elements in Marine Sediments and Tissues— Three separate interlaboratory comparison exercises for environmental contaminants in marine specimens were administered in 2007/2008 by the Chemical Sciences Division. The oldest program is the …

Development of Standard Reference Materials for Vitamins B6 and B12 in Human Serum— Vitamins are essential to normal functioning of the human body because they serve as co-factors for important biological processes. Deficiencies in vitamins B6 and B12 can lead to problems such as …

Development of a Standard Reference Material for Vitamin D in Human Serum— The prevalence of vitamin D deficiency/insufficiency within the general population is an area of concern. Vitamin D status is generally assessed by measuring levels of the metabolite …

Development of Methods for Measurement of Vitamin D in Foods, Fortified Foods, and Dietary Supplements— Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and can contribute to an increased risk of falls and …

Biodiesel SRM Development—The NIST Chemical Sciences Division has collaborated with the Brazil National Institute of Metrology, Standardization and Industrial Quality (INMETRO) on the development of the certified reference …

Micronutrients Measurement Quality Assurance Program— The Micronutrients Measurement Quality Assurance Program, coordinated by the Chemical Sciences Division, supports measurement technology for selected fat- and water-soluble vitamins and …

Bitter Orange Standard Reference Materials— Three bitter orange-containing Standard Reference Materials have been developed as part of the Chemical Science Division's program to produce SRMs related to dietary supplements. Levels of five …

Evaluation of Oleoresin Capsicum (Pepper Spray) Canisters for Chemical Content and Reliability— Aerosol sprays containing oleoresin capsicum, an extract of hot peppers, have been widely used by law enforcement agencies to subdue non-cooperative individuals. Pepper sprays cause incapacitation …

Metrology and Standards for Canine Olfactory Detection of Explosives— As part of a multi-year interagency agreement between the Office of Standards of the Department of Homeland Security and NIST, NIST is developing measurement tools for and providing compositional …

Development of NIST Standard Reference Materials for Trace Explosives Detection— As part of a multiyear interagency agreement between NIST and the Office of Standards of the Department of Homeland Security, NIST is developing a series of Standard Reference Materials (SRMs) to …

SRMs for Contaminants in Air Particulate Matter— In 1997 the U.S. Environmental Protection Agency (EPA) issued new standards for air particulate matter (PM) as part of the national ambient air quality standards, including new regulations for PM …

SRMs for Organic Contaminants in Human Serum, Milk, and Urine—NIST and the Centers for Disease Control and Prevention (CDC) are collaborating to develop seven new SRMs to meet the expanding needs for the measurement of organic contaminants in human fluids: …

Measurements and Standards for Contaminants in Environmental Samples— For the past 40 years NIST has developed SRMs for the determination of inorganic and organic contaminants in environmental matrices such as sediments/soils, marine and animal tissues, air …

Measurement and Standards to Support Nutrition Labeling— The Chemical Sciences Division is working to provide food-matrix reference materials to facilitate compliance with nutritional labeling laws, provide traceability for food exports, improve the …

Reference Measurement Procedures and Materials for Creatinine— Chronic kidney disease (CKD) is a growing problem in the U.S., and current estimates suggest that more than 20 million Americans are affected by this disease. If left untreated, kidney disease can …

Development of a Standard Reference Material for Metabolites in Plasma — Metabolomics is a relatively new field that builds upon work in genomics and proteomics. Metabolomics can provide a unique perspective on the biochemical status of an organism through broad …

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers — The accuracy of clinical diagnostic measurements is essential for reliable diagnosis and cost-effective treatment of disease. NIST's involvement in reference methods and reference materials to …

Fatty Acid Methods and Measurements— The Chemical Sciences Division is working to develop natural-matrix and solution-based SRMs that are characterized for fatty acid composition. The natural-matrix SRMs are intended primarily for …

Botanical Oils Containing Omega-3 and Omega-6 Fatty Acids— The Chemical Sciences Division has developed a collaborative program with the Center for Drug Evaluation and Research (CDER) and the National Institutes of Health's Office of Dietary Supplements …

Saw Palmetto Dietary Supplement Standard Reference Materials— Two Standard Reference Materials containing saw palmetto, SRM 3250 Serenoa repens (Fruit) and SRM 3251 Serenoa repens Extract, have been developed as part of the Chemical Sciences Division’s …

Multivitamin/Multielement Dietary Supplement SRM— The Chemical Sciences Division has produced SRM 3280 Multivitamin/Multielement Tablets for use as a control by laboratories making vitamin or element measurements in similar types of dietary …

Dietary Supplement Analysis Quality Assurance Program— The National Institute of Standards and Technology (NIST) has established a Dietary Supplement Quality Assurance Program (DSQAP) in collaboration with the National Institutes of Health (NIH) …

Development of Serum-Based SRMs to Assess Nutritional Status— A variety of nutrients are essential for normal functioning of the human body, and deficiencies can lead to serious illnesses. Accurate measurement of vitamin levels is therefore essential for …

Measurements and Standards for Botanical Dietary Supplements— As part of a multi-year interagency agreement among the National Institute of Standards and Technology (NIST), the National Institutes of Health's Office of Dietary Supplements (NIH/ODS), the Food …

CCQM Activities in the Organic Analysis Working Group— NIST's Analytical Chemistry Division has participated in over 50 Consultative Committee for Amount of Substance - Metrology in Chemistry (CCQM) Organic Analysis Working Group (OAWG) studies since …

Novel Stationary Phase Materials in Separation Science Research— Research activities in separation science continue to focus on investigations of the fundamental physical and chemical processes that influence analyte retention in liquid chromatography (LC), as …

Molecular Simulation of Stationary Phase Materials in Liquid Chromatography— Molecular simulation models of monomeric and polymeric stationary phases used for liquid chromatography have been employed to investigate the molecular-level structural features that control …

Comprehensive Two-Dimensional Gas Chromatography/Time of Flight Mass Spectrometry (GC x GC/TOF-MS)— Although conventional gas chromatography mass spectrometry (GC/MS) provides relatively high efficiency separations, the analysis of some complex, natural-matrix samples may require the use of even …