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Standards and measurement science for quantitative medical imaging


Develop precision calibration standards for accurate determination of feature sizes in computed tomography images, to improve reliability of measurements of drug response, thus reducing time and costs of clinical trials.


Broad Long Term Objectives:

Demonstrate the positive impact/value of a national standard phantom for thoracic CT developed by NIST and also the impact of algorithms developed to analyze CT scans obtained on that phantom on clinical trials that include CT of the thorax.  Specifically demonstrate that the use of this phantom will decrease the variability in scans among different CT scanners which will in turn reduce the error in measurement of
Validate that the phantom developed by NIST is an acceptable model for the human thorax in the sense that the ability of a CT scanner to accurately depict the phantom correlates highly with its ability to accurately represent a human thorax

Demonstrate that the use of imaging informatics software developed by the National Cancer Institute’s caBIG imaging workspace including the National Biomedical Imaging Archive can lower the barriers to rapid analysis of CT scanner image quality by decreasing the cost and time required to evaluate the images of the phantom.

Serve as a quality assurance resource for the proposed quantitative imaging network that will be established by the investigators that are awarded funding to establish the network.

<font color="#006400"><strong>NIST-provided phantoms in a CT scanner at the University of Maryland.</strong></font>

Start Date:

January 1, 2009

End Date:


Lead Organizational Unit:



Zachary Levine (844)

Charles Fenimore (894)

Brian E. Zimmerman (846)


General Information:
301-975-3708 Telephone
301-208-6937 Facsimile

100 Bureau Drive, MS 8410
Gaithersburg, MD 20899-8410