Proteomics

News and Updates

Petri dish holds brown material with several different types of circular microbes.

Spotlight: Going With the Gut for the Future of Health

June 27, 2022

NIST researchers are developing a human gut microbiome reference material.

Woman uses gas analysis mass spectrometer at NBS for chemical analysis of gas or vapor mixtures

NIST Adds New 'Fingerprints' to Chemical Identification Database

June 17, 2020

The National Institute of Standards and Technology (NIST) has updated its database of chemical fingerprints, called mass spectra, that are used to identify

A Solution to a Hairy Problem in Forensic Science

November 5, 2019

In an effort to make hair comparison a more useful technique for investigating crimes, scientists at the National Institute of Standards and Technology (NIST)

Projects and Programs

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

A new collaboration between NIST's Human Genomics Team, Mass Spectrometry Data Center, and Information Technology Laboratory to use and develop artificial

Photograph of a mylar bag and amber vial labeled 1950 metabolites in Human Plasma

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years

Human Gut Microbiome Reference Material

Ongoing

To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need

NIST Urine Albumin Standardization Program

Ongoing

The NIST Urine Albumin Standardization Program is focused on the development of a measurement procedure and reference materials to support an international

Publications

Comparison of N-glycopeptide to released N-glycan abundances and the influence of glycopeptide mass and charge state on N-linked glycosylation of IgG antibodies

March 7, 2024

Author(s)

Concepcion Remoroza, Meghan Burke Harris, Tytus Mak, Sergey Sheetlin, Yuri Mirokhin, Zachary Goecker, Brian T. Cooper, Mark Lowenthal, Xiaoyu (Sara) Yang, Guanghui Wang, Dmitrii V. Tchekhovskoi, Stephen E. Stein

We report the comparison of mass-spectral-based abundances of tryptic glycopeptides to fluorescence abundances of released labeled glycans and the effects of

Narrowing Signal Distribution by Adamantane Derivatization for Amino Acid Identification Using α-Hemolysin Nanopore

January 24, 2024

Author(s)

Xiaojun Wei, Dumei Ma, Junlin Ou, Ge Song, Jiawei Guo, Joseph Robertson, Yi Wang, Qian Wang, Chang Liu

Nanopores have demonstrated remarkable sensitivity as biosensors, enabling the sequencing of DNA and RNA at the single-molecule level. The rapid progress in

A multipathway phosphopeptide standard for rapid phosphoproteomics assay development

August 30, 2023

Author(s)

Brian Searle, Allis Chien, Antonius Koller, David Hawke, Anthony Herren, Jenny Kim, Kimberly Lee, Ryan Leib, Alissa Nelson, Jian Min Ren, Paul Stemmer, Yiying Zhu, Ben Neely, Bhavin Patel

Recent advances in methodology have made phosphopeptide analysis a tractable problem for many proteomics researchers. There are now a wide variety of robust and

Proteomics as a metrological tool to evaluate genome annotation accuracy following de novo genome assembly: a case study using the Atlantic bottlenose dolphin (Tursiops truncatus)

August 25, 2023

Author(s)

Ben Neely, Debra Ellisor, Clay Davis

The last decade has witnessed dramatic improvements in whole-genome sequencing capabilities coupled to drastically decreased costs, leading to an inundation of

Awards

John Marino Honored with Hillebrand Prize

John Marino is recognized for his groundbreaking contributions to the field of biophysical characterization by high-resolution NMR and