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Material Measurement Laboratory / Biomolecular Measurement Division

Bioanalytical Science Group

Projects/Programs

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      Displaying 1 - 13 of 13
      Bioman lifecycle

      Biomanufacturing Initiative

      Ongoing
      The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in

      Development of Proteomics-Based Methods for Protein Quantification

      Ongoing
      Reference measurement procedures and standard reference materials help ensure that routine clinical assays provide accurate results across different laboratories and over time. Lists of such higher-order methods are published by the Joint Committee for Traceability in Laboratory Medicine (JCTLM)

      Development of Reference Methods and Reference Materials for Proteins

      Ongoing
      Accuracy and comparability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. A clinical comparison among 14 commercial assay platforms revealed more than 20-fold
      13 tubes each containing an individual glycan in SRM 3655

      Glycan Standard Reference Materials

      Ongoing
      Now Available A glycan-based NIST Standard Reference Material ( SRM 3655 Glycans in Solution) supports the biomanufacturing and protein therapeutics communities with a set of 13 individually-bottled, pure glycoforms including those most commonly observed as N-linked glycans on therapeutic monoclonal
      Montage of photographs depicting eggs, almonds, grain, milk, strawberries, fish, peanuts, and soybeans.

      NIST Food Protein Allergen Program

      Ongoing
      Food allergen management is an increasingly important economic and public health concern; therefore, accurate and reliable allergen measurements are a crucial component of the management pathway. Traditional methods for food allergen detection are based on immunoassay techniques and are linked to a
      photo collage of meats, cheese, eggs, fish, and shellfish

      NIST Food Safety Program

      Ongoing
      The Food Safety Program at the National Institute of Standards and Technology (NIST) provides advanced analytical chemistry and quantitative biology to ensure that food is free of contaminants and allergens and is authentic, promoting U.S. manufacturers’ participation in domestic and foreign markets
      NISTmAb RM8671 vial and 3D printed model

      NIST Monoclonal Antibody Reference Material 8671

      Ongoing
      The NISTmAb material is a recombinant humanized IgG1κ expressed in murine suspension culture. It is an »150 kDa homodimer of two identical light chains and two identical heavy chains linked through both inter- and intra-chain disulfide bonds. The protein has low abundance post-translational
      Reference Measurement System for Urine Albumin

      NIST Urine Albumin Standardization Program

      Ongoing
      Kidney disease is a major global economic and public health issue, with chronic kidney disease (CKD) representing one of the top 10 most prominent causes of death worldwide. The public health and economic impact of CKD and other kidney diseases has led to the need for the accurate detection of

      Targeting Membrane Proteins

      Ongoing
      Membrane proteins constitute approximately 30% of all cellular proteins. Nevertheless, this group of proteins is traditionally understudied due to limitations of the available analytical tools. Given the importance of membrane proteins in the various cellular processes and their potential as drug