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Chemistry

Projects/Programs

Displaying 26 - 50 of 173

Computational Chemistry

Ongoing
Given the combinatorial possibilities for combining fundamental elements to create novel molecules, bench science experimentation is impractical as a wholesale means to discovery. By contrast, computational resources abound and thereby offer a possible alternative. However, this immense resource is
component 1

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing
‘Omics is increasingly moving out of the laboratory and towards use in industrial and commercial applications. For instance, in biomanufacturing, there is a need for quality control when developing biotherapeutics, which will almost certainly require a machine-learning classifier to separate
NIST researcher setting up air cleaner experiments in large stainless steel environmental chamber

Contaminant Control in High-Performance Buildings

Ongoing
Objective To better understand how strategies to achieve resilient buildings will impact chemical reactions, rates, and concentrations of high-priority indoor air contaminants. To develop test methods and building control strategies to reduce chemical levels in low-energy buildings, and to enable
Photograph of SRM 114r Portland Cement Fineness Standard showing labeled mylar bag and vial.

Continuing Support of Cement Manufacturing

Ongoing
NIST SRMs for Portland cement and related materials are the de facto world standards for validation of analytical methods for testing of cement for compliance with manufacturing specifications and for qualification of laboratories throughout the supply chain, including cement plants, construction
Cover of the ASME International Steam Tables for Industrial Use, Third Edition

Contributions to International Standards on the Properties of Water

Ongoing
Water is probably the most widely used industrial fluid and it is important to have internationally accepted standards for its properties. This information is crucial to the analysis and design of thermal power cycles, as well as for climate studies including the hydrosphere. (Here is a summary of

Controlling Microfluidic Cell Cultures

Completed
Intended impact: Cell behavior is powerfully modulated by local extracellular cues. However, the number of parameters that affect cell behavior is large, and include soluble signaling molecules, dissolved gases, the chemistry and mechanics of the extracellular matrix, and the proximity and behavior

Development of differential absorption LIDAR Technologies

Ongoing
The basic processes involved in elastic backscatter LIDAR are as follows. A laser emits a pulse of light (typically a few nanoseconds), and as the pulse propagates, the photons interact with molecules and aerosol particles. Some of these, the interactions with aerosols, such as Mie and Rayleigh

Development of Enhanced mRNA Amplification Using Microfluidics

Completed
Intended Impact Tissue samples frequently contain multiple cell types. New methods (e.g. laser capture microdissection) enable the segregation of small quantities of individual cells and cell types, but the current methods to analyze global gene expression do not provide highly efficient profiling

Development of Proteomics-Based Methods for Protein Quantification

Ongoing
Reference measurement procedures and standard reference materials help ensure that routine clinical assays provide accurate results across different laboratories and over time. Lists of such higher-order methods are published by the Joint Committee for Traceability in Laboratory Medicine (JCTLM)

Development of Reference Methods and Reference Materials for Proteins

Ongoing
Accuracy and comparability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. A clinical comparison among 14 commercial assay platforms revealed more than 20-fold
Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing
Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of
Dietary QAP

Dietary Supplement Laboratory Quality Assurance Program (DSQAP)

Ongoing
Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing an annual expenditure of more than $20 billion. Regulations, driven by reported cases of inaccurate labeling, adulteration, contamination (with pesticides, heavy metals, or
Dietary QAP

Dietary Supplement Laboratory Quality Assurance Program (DSQAP) Consortium

Ongoing
The objective of the DSQAP Consortium is to develop and evaluate measurement methods and standards to support quality and safety for the dietary supplement testing community. Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing
Instrumentation that create and read droplets for digital PCR measurements.

Digital PCR

Ongoing
With appropriately validated assays, digital polymerase chain reaction (dPCR) determines the number of DNA targets (copies) per reaction partition, without the need for a standard curve. Reaction partitions can be in the form of fixed chambers in a microfluidic device, referred to as chamber digital

Electrochemistry

Ongoing
Operando Measurements Measurements of the structure and dynamics of metal-electrolyte interfaces are essential for understanding mechanisms of electrocatalysis and electrodeposition that are key to optimization of materials processing and utilization in wet chemical environments. Our measurement
Electron micrographs of representative as-synthesized MNPs for thermometry.

Engineering and Optical Characterization of Magnetic Nanoparticles (MNPs)

Completed
Nanomagnets by Design Nanoparticles are an important subclass of low-dimensional magnetic materials displaying size-dependent magnetic behavior. The controllable magnetocrystalline anisotropy introduced at nanoscale size regimes (as low as 3 nms in diameter) allows for MNPs of ferro/ferrimagnetic
Hexagon containing words “environmental metabolomics” with arrows pointing from the hexagon to each of the following images: coral, shrimp, mussel, microbe, horseshoe crab, plant. The circle figure has waves and a tree faded in the background.

Environmental Metabolomics

Ongoing
The application of metabolomics techniques to environmental systems biology offers a promising opportunity to achieve insights into non-model organism biology. Each biological system manifests distinctive challenges that offer insights into criteria important for rigorous study design and method