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Chemistry

Projects/Programs

Displaying 76 - 100 of 172
Map of the world, with six colors used to identify the six regional metrology organizations.

International Comparisons for Chemical Measurements

Ongoing
International agreements and decisions concerning trade and our social well-being increasingly require mutual recognition of measurements and tests among nations. The Mutual Recognition Arrangement (MRA) on national measurement standards and calibration and measurement certificates issued by NMIs
Figure with the word “isotope” and related icons superimposed on a photograph of a man pointing to the figure.

Isotope Metrology

Ongoing
The application of isotope measurements drives advances in an enormous number of fields and stakeholder engagements, including federal and state government agencies, academia, and private industry including the medical industry. The objective of the NIST Isotope Metrology Program is to address the
SPRI Cells

Label-free imaging of cells and their extracellular matrix by SPR imaging

Ongoing
Cellular remodeling of their neighboring environment, extracellular matrix (ECM), is an important biological process from development biology, to wound healing, to diseases and cancers – this is a challenging process to measure and quantify. Surface plasmon resonance imaging (SPRI) has been

Low Temperature Regenerator and Pulse Tube Losses

Ongoing
All-digital radio communication between the various forces of the U.S. military is required to improve communications to the level needed in the near future. Such communication requires analog-to-digital converters of speeds only possible with low temperature superconducting electronics. The
MLF_EquationofState1

Machine Learning Fluid Equations of State

Ongoing
Understanding the thermodynamic properties of fluids and fluid mixtures is of central importance in many fields of science and engineering ranging from medicine to consumer products. The nature of the particles in a fluid can vary greatly depending on the type of interactions present, e.g., dipole
Multi_Colloidal_Crystals2

Machine Learning to Predict Multicomponent Colloidal Crystals

Ongoing
There is a direct link between a material’s macroscopic properties and its microscopic structure, which makes rational bottom-up self-assembly a powerful tool for engineering properties of materials. In general, colloids are facile material building blocks whose shape, charge, and surface

Macromolecular Architectures

Ongoing
This project’s purpose is to synthesize and characterize model thermoplastics, thermoplastic elastomers (TPE), and mixed resins with systematic variation of polymer sequence, chemistry, and architectures to generate libraries of quantitative structure-property relationships validated by multiple

Magnetic Sector Secondary Ion Mass Spectrometry

Ongoing
Magnetic sector SIMS uses high energy “primary” ions to bombard the surface and liberate “secondary” ions much like in ToF-SIMS, but the ion beam is operated continuously to maximize duty cycle. The high ion dose is preferred for depth profiling, where the concentration of elements and isotopes are
MGI goals

Materials Informatics

Ongoing
To develop the need data infrastructure and informatics tools, NIST is focusing on three areas: data curation, data infrastructure, and data access. Data curation efforts include efforts to develop a phase-based materials ontology to ensure that the data is represented in a semantically

Measuring Intermolecular Interactions with Electro-Acoustic Spectroscopy

Ongoing
We have a number of opportunities to collaborate with us. See below for details. What does this project aim to do for the chemical industry? Many industrial processes depend on the intermolecular environment- the solvents and ions that surround a molecule. These interactions impact separations
Schematic of approach to clean water membranes

Membranes for Clean Water

Completed
Impact Access to affordable, clean water is vital to the nation's economic growth and security. Polymer-based membrane separation technologies based on reverse osmosis, forward osmosis and nanofiltration will play an increasingly critical role in the production of clean, safe water. In order to
MANTA Logo

Method Assessment for Non-Targeted Analyses (MANTA) Program

Ongoing
Typical targeted analysis aims to detect and/or quantify a set of known chemical compounds using specific instrumental techniques (such as liquid chromatography with triple quadrupole mass spectrometry). In contrast, non-targeted analysis is an analytical technique that detects, identifies, and/or
Fab Domain from NISTmAb

Metrologies for Protein Structure, Dynamics and Function

Ongoing
Based on its established expertise, infrastructure, and resources for structure/function studies of biological macromolecules, the program aims to impact advances in physics, chemistry, and engineering relevant to biological problems. NIST researchers also develop new technologies for application to
Illustration showing examples of acidic, neutral and alkaline pH values ranging from 0 to 14 that include battery, stomach acid, lemon, soda, tomato, coffee, milk, water, blood, egg white, stomach tablets, ammonia solution, soap, bleach and drain cleaner.

pH Metrology

Ongoing
The suite of NIST pH SRMs forms the basis for pH measurements in the United States, and pH is the most-often-measured chemical quantity. Hence this NIST work directly or indirectly impacts a large number of users in industry, government, and academia. One of the most critical set of users is in
Photograph of a dog sniffing luggage.

Metrology and Standards for Canine Olfactory Detection of Explosives

Effective and accepted by the public, trained dogs are the most frequently deployed detection systems for identification of explosives threats in mobile applications. In addition to being highly sensitive, dogs can rapidly discriminate the unique profile of an explosive in a presence of a large

Microcryocooler for Terahertz Detectors

Ongoing
DARPA has been interested in the development of cooled detector systems (infrared and terahertz) that require less than 1 W of input power (battery operated) and have a total volume less than about 4 cm 3. Such systems could be used for detection of enemy missile launches (infrared), chemical
MMQAP figure

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed
The MMQAP supported the long-term (months to years) reliability of selected fat- or water-soluble vitamin measurements in human serum and plasma. Results from the comparison studies helped participants to make accurate clinical and health-care decisions as well as to maintain and improve their
A stainless steel micro tensile specimen in a silicon frame.

Microsystems for Harsh Environment Testing

Completed
Classically, measurement of the mechanical properties and reliability of bulk-scale materials is performed with macroscopic specimens and methods. Specimen preparation limitations, miniaturized load-frame tooling problems, and inadequate understanding of the roles of specimen size and constraint on
Two-dimensional chromatogram showing the separation of four compounds as shaded elliptical areas

Multidimensional Chromatography

Ongoing
The development of robust analytical methods remains one of the most important (and costly) parts of chemical metrology. The separation of targeted constituents from other components in a sample matrix is necessary for accurate and precise measurements. Multidimensional chromatography is an

Multiplexed "Detectorless" Electrophoresis

Ongoing
Intended impact:In the biological sciences, there is an increasing need for measurement tools that can provide high-throughput, high-quality data (consider drug discovery and systems biology, for example). Capillary electrophoresis (CE) is fast, requires only small amounts of sample and reagents

Nanoscale Thermal Properties

Completed
It is known that at the nanoscale, composition and interface structure play important roles in determining the mechanical, thermal, and electrical properties of multiphase nanomaterials and nanocomposites. To probe the thermal properties of these heterogeneous nanomaterials, local thermal analysis