Projects/Programs

Displaying 1 - 14 of 14

Video microscopic image - Rotation and translation.

Control of Magnetic Nanoparticles for Nanoscale Manipulation of Fluids and Materials (Archived)

Completed

Low Reynolds number swimming, or motion through a viscous fluid, is a technique at which nature is adept. Bacteria, protists, and algal cells live in a regime where viscous effects dominate inertial ones. As these microscale biological swimmers move, they perturb the fluid around them, affecting

Controlling Microfluidic Cell Cultures

Completed

Intended impact: Cell behavior is powerfully modulated by local extracellular cues. However, the number of parameters that affect cell behavior is large, and include soluble signaling molecules, dissolved gases, the chemistry and mechanics of the extracellular matrix, and the proximity and behavior

Development of surface functionalized engineered nanomaterials for biological applications

Ongoing

The main research theme is the design and implementation of novel surface functionalities on engineered nanomaterials, by chemical approach, for biological applications. This project involves (1) the creation of biocompatible nanomaterial systems as drug delivery templates, (2) characterization of

Schematic showing DNA origami in a laser beam

DNA Origami for Precise Manufacturing of Nanoscale Structures

Completed

The base pairing of adenine to thymine and guanine to cytosine to form DNA provides a robust molecular recognition scheme that can be used to create a wide variety of well-ordered nanostructures. DNA origami, which uses a long scaffold strand folded together by specific sets of short staple strands

Fundamental Interaction Mechanisms of Engineered Nanomaterials with DNA

Completed

Intended impact Nanotechnology research has resulted in the rapid creation of engineered nanomaterials with many foreseeable applications in medical imaging/diagnosis and in drug delivery. However, there is a notable scarcity of both acute and chronic human toxicity data for these new materials

Measurements for minimal cells

Ongoing

Minimal cells are cells whose genome has been stripped of all but those genes essential for replication, in a process called "genome minimization." NIST and collaborators demonstrated genome minimization coupled to single cell imaging as a powerful approach to investigate the minimal genetic

Metrologies for Nanobiomaterials in Artificial Photosynthesis

Completed

A transition to solar fuel will require high-efficiency catalysts that make use of domestic fuel feedstocks with minimal additional energy input. In the past several years, novel water oxidation catalysts from abundant elements have been reported. Catalysts deposited onto a photoactive substrate

A micromechanical bulk acoustic resonator that uses phononic crystal tethers to achieve a quality factor approaching the fundamental dissipation limit (fxQ can be as large as 1.2 x 1013 Hz)

Micro- and Nanoelectromechanical Systems

Completed

MEMS/NEMS are enabling technologies that bring new functionalities with the potential to radically transform markets ranging from consumer products to national defense. The meteoric rise of the smartphone is an excellent example, in which MEMS accelerometers, gyroscopes, microphones, displays, and

Molecular Physiology

Ongoing

In close collaboration with experimentalists, we are seeking to increase the resolution, scope, and throughput of single-biomolecule and ensemble techniques, such as nanopore-based biomolecular analysis, ultrafast vibrational spectroscopy, and FRET, among others. These developments rely heavily on

Nano-biophotonics for molecular imaging

Ongoing

Nano-biophotonics consists of four broad areas: molecular bioimaging; nano-biosensors; multiplexed bioassays ; and nanotechnology-based medical practices for diagnosis and therapy. Success in these areas is challenged by the underlying complexity of biological systems. Major levels of complexity and

Nanometrology: Composition and Structure of Nanomaterials

Ongoing

Pushing the Limits of Measurement Accuracy in Atom Probe Mass Spectrometry Nanoscale Analysis of Biological and Organic Materials Release from Nanocomposite Consumer Products

Nanoscale Spectroscopy for Advanced Electronics, Quantum Materials and Devices

Ongoing

Semiconductor technologies are critical to U.S. economic and national security as they are essential to modern life in communications, healthcare, energy, etc. and also underpin many emerging technologies like quantum, artificial intelligence, high power electronics and advanced wireless (6G+). The

Sensing, Transport, and Simulation

Ongoing

We have recently developed a finite-size scaling approach and special simulation cell aspect ratio—the golden aspect ratio—to enable accurate incorporation of access resistant and bulk diffusion in ionic transport, see the figure. This enables quantitative, and efficient, prediction of ion transport

Single-molecule biosensors

Ongoing

We are developing new tools to investigate the energy landscape of single-molecule sensors. Our goal is to apply a wide-ranging array of technologies to probe the critical physicochemical properties of nanopore biosensors. These properties include the free energy of confinement for polymers as they

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