Projects/Programs

Displaying 1 - 23 of 23

Aerodynamic Flow Visualization

Ongoing

Other videos: How Well Do Masks Work? (Schlieren Imaging In Slow Motion!) 3 Ways Of Seeing Invisible Air Flow (Veritasium) The Air You Share | All in This Together Publications "Filter Inserts Impact Cloth Mask Performance against Nano- to Micro-Sized Particles" James G. Radney, Jamie L. Weaver

Ambient and Atmospheric Pressure Mass Spectrometry

Ongoing

Surface and Trace Chemical Analysis Group employs a range of commercial pneumatically-assisted electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) sources for traditional mass spectrometric chemical analysis, identification

DARPA Friend or Foe (FoF) – Independent Verification and Validation (IV&V)

Completed

Vision Validate new measurement platforms for identifying commensal (friend) and pathogenic (foe) microorganisms Goal Provide well-characterized, microbial community reference materials of increasing complexity Approach Start with well-characterized pure cultures and scale up to complex consortia in

Documentary Standards: X-ray Security Screening Applications

Ongoing

This work fills well-documented gaps in transportation security, which have been highlighted in Executive and Legislative requirements for 100 % screening of baggage, cargo, and airline passengers. This is accomplished through a corpus of new standards, test methods, test artifacts, dosimetry

Ammunition metal box with explosives sticker.

Explosives Decomposition Chemistry

Completed

Intended Impact Computational modeling and simulation will help in the invention of new explosives, the design of compounded mixtures of existing materials, and the engineering of delivered systems such as military ordnance. Objective Detailed chemistry is a necessary part of computational

Illicit Narcotics Detection

Ongoing

“Method for evaluating ion mobility spectrometers for trace detection of fentanyl and fentanyl-related substances”, Jennifer R Verkouteren, Jeffrey Lawrence, R Michael Verkouteren and Edward Sisco, Analytical Methods, 11(47), 6043-6052 (2019). “Discriminative potential of ion mobility spectrometry

Ion Mobility Spectrometry

Ongoing

IMS employs a drift tube with an applied electric field to separate ionized molecules based on their mobility. The technique is robust and capable of differentiating a wide range of drug and explosive molecules. Recent work has sought to investigate the utility of IMS for screening of illicit

Living Yeast Cell Reference Material (RM 8230)

Ongoing

Quantification of total and viable microbial cells is critical for applications ranging from assessment of DNA extraction efficiency in support of microbial metagenomics to characterization of antimicrobial efficacy. In addition, safe biological materials are needed to substitute for true biothreat

Measurement and Sampling Standards

Ongoing

A foundational activity that crosscuts our research goals is the development of a variety of standards and test materials to support the effective operation of trace explosive and narcotic detection devices. Trace sampling issues are addressed through fundamental studies on the adhesion and

Metrology and Standards for Canine Olfactory Detection of Explosives

Effective and accepted by the public, trained dogs are the most frequently deployed detection systems for identification of explosives threats in mobile applications. In addition to being highly sensitive, dogs can rapidly discriminate the unique profile of an explosive in a presence of a large

Nanocalorimetry Measurements

Ongoing

Accurate thermodynamic measurements are essential to understand fundamental properties of materials, providing direct and quantifiable insight into the thermodynamics of thin film reactions and phase transitions. Going forward, new classes of materials may only be synthesized as thin films, a scale

Nature of the Threat

Ongoing

"Improving Particle Collection Efficiency of Sampling Wipes used for Trace Chemical Detection", Gillen, Greg and Lawrence, Jeffrey and Sisco, Edward and Staymates, Matthew E. and Verkouteren, Jennifer and Robinson, Elizabeth L. and Bulk, Alexander, Anal. Methods, 14, 581-587 (2022). http://dx.doi

Open Port Liquid Interface Mass Spectrometry

Ongoing

Rapid screening for chemical traces of explosives and narcotics is widely used to support homeland security and law enforcement. These target compounds span a range of physicochemical properties from organic to inorganic, with preferential ionization pathways in both negative and positive mode

Optimization of Current and Next Generation Trace Contraband Detection Systems

Ongoing

Ion Mobility Spectrometry (IMS) is widely used for national security and law enforcement, placed at key security checkpoints such as airports and border crossings for the trace detection of drugs and explosives. Its simplicity, ease of operation, portability, and rapid analytical performance

Security (archive): X-ray Systems for Cargo and Vehicle Inspection Systems

Completed

The American National Standards Institute (ANSI) standard for the image quality indicators of non-intrusive cargo and vehicle inspection systems, ANSI N42.46, was previously developed through a series of meetings hosted by NIST. NIST has conducted and analyzed the results of tests using this

Standards to Support Biological Detection in the Field

Ongoing

NIST is working in partnership with the Department of Homeland Security Science and Technology Directorate (DHS S&T) to develop methods, guidance, standards, and reference materials to support and improve our Nation's ability to detect and respond to suspected biothreat incidents. Specific

First responders collecting samples of the yeast surrogate material during a field exercise. (Credit: NIST)

Standards to Support Biothreat Detection

Ongoing

Since 9/11 and the subsequent anthrax attacks in 2001, suspicious white powder incidents continue to occur within the US, often requiring Federal law enforcement response. Suspect samples are sent to public health laboratories for confirmatory evaluation, which can take hours to weeks to receive

Surface Desorption Ambient Mass Spectrometry

Ongoing

The Surface and Trace Chemical Analysis Group maintains a range of research avenues into the characterization, analysis, and optimization of various commercial and in-house developed surface desorption ion sources. These research avenues also aim to advance our fundamental understanding of the

Surrogate Materials to Support Training in Biological Sampling and Detection in the Field

Ongoing

Nationwide, first responders regularly encounter suspicious materials that might be biological threat agents. Routine training and process evaluations help ensure workflows, operators, and technologies are working together properly within the concept of operations. Biological test materials have the

Thermal Desorption Ambient Mass Spectrometry

Ongoing

The Surface and Trace Chemical Analysis Group is involved in a number of research avenues for the rapid screening of wipe-collected samples for the security and forensic chemistry fields. Similar to the widely-deploy ion mobility spectrometry (IMS) systems for screening, this is accomplished through

Trace Contraband Detection

Ongoing

Screening of people and their belongings including luggage, vehicles, and packages for the presence of trace residues of explosives and narcotics (trace contraband detection) is widely used in aviation security and law enforcement. In common screening scenarios, trace contraband residues in the form

Vapor Sampling in the Field

Ongoing

Breath sampling of cannabis users. Several versions of breath collection devices are being marketed for the detection of THC (delta-9-tetrahydrocannabinol) in the breath of cannabis users. THC is not directly correlated to intoxication but may indicate recent smoking or vaping. THC and other

Vapor Sampling to Support Public Safety and Forensics

Ongoing

Vapor pressures of unstable, reactive compounds. Over the last decade, our group has investigated a variety of low-volatility compounds including taggants (found in explosives), biofuels, terpenes and cannabinoids. Dynamic vapor microextraction (DVME), developed at NIST, is a small-volume dynamic

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