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Health

Human microbiome

Projects/Programs

Displaying 1 - 11 of 11

Combating Antibiotic Resistance

Ongoing
We are developing in vitro systems to generate controlled chemical and community environments that mimic the features of real-world that are important determinants for evolutionary rate and resistance potential. In addition, we are developing tools to isolate and analyze single bacteria along the
GutMicrobiome

Gut Microbiome Metabolomics Interlaboratory Program

Ongoing
On behalf of the Biosystems and Biomaterials and Chemical Sciences Divisions at the National Institute of Standards and Technology (NIST), we would like to thank you for your interest in our new Gut Microbiome Metabolomics Program. As part of the larger NIST Microbiome Program, this metabolomics

Human Gut Microbiome Reference Material

Ongoing
The most common measurements currently being used to describe these complex microbial communities are: NGS-based metagenomics Mass spectrometry-based metabolomics In either case, no fit-for-purpose standards exist that enable researchers to compare results generated across different laboratories and

Measuring Antimicrobial Resistance

Ongoing
Antibiotic resistance has been identified in the Nation’s Action Plan to improve the health and wellbeing of the American people. NIST scientists are leveraging a wide range of measurement capabilities to study microbial community dynamics with regard to antimicrobial resistance. Using a range of

Methods to Quantify Microbial Viability

Ongoing
Validating DNA-based methods to quantify viable bacteria ( S. Da Silva , G. Pinheiro) Microbial detection technologies based on nucleic acid measurements, such as polymerase chain reaction (PCR), are powerful detection tools that can provide relatively rapid results as compared to traditional
Figure showing four components of metabolomics with samples and processing

Microbial Metabolomics

Ongoing
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are widely used and complementary analytical platforms for the characterization, identification, and quantification of a metabolome. MS techniques, typically coupled to chromatography, provide a chemical fingerprint of complex
Microbial Strain

NIST Microbial Strain Collection

Ongoing
Microorganisms of interest include but are not limited to those relevant to: biomanufacturing of advanced therapy products; rapid microbial testing; microbial therapeutics (e.g., live biotherapeutic products, probiotics, and fecal microbiota transplantations (FMTs)); infectious disease
Research Grade Testing Material (RGTM 10212), Synthetic Fecal Metabolite Calibrant (Credit: NIST)

Synthetic Fecal Metabolite Calibrant Solution (RGTM 10212)

Ongoing
Metabolomics is an exciting and dynamic field in life sciences that harnesses cutting-edge technologies to identify and characterize small molecules, or metabolites, within cells, tissues, or organisms, collectively known as the metabolome. The wealth of evidence in the literature underscores the

Wastewater Surveillance

Ongoing
NIST is partnering with the Department of Homeland Security Science and Technology Directorate (DHS/S&T) to develop documentary standards and reference materials to support an enduring capability in wastewater surveillance. Ongoing activities include: Development of a research grade test material