U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Projects/Programs

Topic Area
Displaying 376 - 400 of 1616

Development of Reference Methods and Reference Materials for Proteins

Ongoing
Accuracy and comparability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. A clinical comparison among 14 commercial assay platforms revealed more than 20-fold
Photograph of SRM 3950 Vitamin B6 in Frozen Human Serum with labeled box and frosty capped bottles containing level 1 and level 2.

Development of Serum-Based SRMs to Assess Nutritional Status

Ongoing
Vitamin deficiencies are generally considered rare in the U.S., but a growing body of evidence suggests that certain deficiencies may be more prevalent than originally thought. For example, it has been estimated that 10 % to 15 % of adults over the age of sixty are affected by vitamin B 12
Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing
Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of
GC-ICP-MS Chromatogram

Development of SRM 955c Toxic Elements in Caprine Blood

Completed
Intended Impact Over the last three decades, NIST, with support from the Centers for Disease Control (CDC), and in conjunction with the New York State Department of Health’s (NYSDOH) Wadsworth Center, has produced a number of frozen whole blood certified reference materials containing endogenous

Device-level Anomaly fRamEwork (DARE)

Ongoing
A collaborative NIST team is taking a multi-disciplinary approach in cybersecurity, wireless communications, and machine learning. The DARE project leverages NIST's diligent approach and capabilities, including detailed use cases, design of experiments with rigorous multilayer measurements, and
Lattice constant for AI using various exchange-correlation functionals

DFT Benchmarking

Ongoing
Since its inception exactly 50 years ago this year, density-functional theory (DFT) has evolved from an exotic idea of physicists into the most-widely used tool for the computational prediction of materials’ structures and electronic, optical, magnetic, and mechanical properties. While DFT presents

DFT Repositories and Informatics

Ongoing
Historically, the printed article has served as the medium de rigueur for the dissemination of scientific information. This works well when the context and results of an experiment or theory fit on a few pages; however, it is insufficient as a publication medium for many computational studies. For

DHS-OEC Next Generation Networks – Priority Services Evaluation Project

Ongoing
The Department of Homeland Security’s Office of Emergency Communication (DHS-OEC) is responsible for administering both the Government Emergency Telecommunications Service (GETS) and Wireless Priority Service (WPS) programs. Both programs offer their users an alternative method for call completion

DHS-OEC Next Generation Networks – Priority Services Evaluation Project

Ongoing
The Department of Homeland Security’s Office of Emergency Communication (DHS-OEC) is responsible for administering both the Government Emergency Telecommunications Service (GETS) and Wireless Priority Service (WPS) programs. Both programs offer their users an alternative method for call completion
Nitrogen-vacancy center in a diamond crystal

Diamond NV Center Magnetometry

Ongoing
A flaw in a crystal might not be an intuitive choice for a measurement tool, but the nitrogen-vacancy (NV-) defect in diamond is something special. Using light, we prepare the NV- center’s the quantum spin state, it interacts with magnetic fields, and we read out the resulting spin state through
Dietary QAP

Dietary Supplement Laboratory Quality Assurance Program (DSQAP)

Ongoing
Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing an annual expenditure of more than $20 billion. Regulations, driven by reported cases of inaccurate labeling, adulteration, contamination (with pesticides, heavy metals, or
Figure 1. Class of optical setup considered in this work. The aperture can be limiting (as shown in this case) or nonlimiting.

Diffraction effects in radiometry

Ongoing
Essentially, classical radiometry relies on geometrical optics (to relate source radiance), geometrical aspects of an optical layout, and the irradiance at the detector. One considers the propagation of radiation from points on the surface of the source to points on the surface of the detector. In
Picture of PBD set up for wavelength measurement

Diffraction Metrology and Standards

Ongoing
Diffraction techniques can provide data on a number of sample characteristics. Therefore, the method of certification and the artifact itself are chosen to address a specific measurement issue pertinent to a diffraction experiment. NIST diffraction SRMs may be divided into five groups: Line Position

Digital Forensics

Ongoing
The project team develops tools for testing computer forensic software, including test criteria and test sets. ITL also maintains the National Software Reference Library – a vast archive of published software applications that is an important resource for both criminal investigators and historians.

Digital PCR

Ongoing
With appropriately validated assays, digital polymerase chain reaction (dPCR) determines the number of DNA targets (copies) per reaction partition, without the need for a standard curve. Reaction partitions can be in the form of fixed chambers in a microfluidic device, referred to as chamber digital

Digital Thread for Manufacturing

Ongoing
Purpose and Goals This project will provide research advances in product-definition standardization, conformance testing, and cybersecurity of data assets. Digital thread standards capabilities and infrastructure - Smart connected manufacturing requires the effective communication of the product

Digital Thread for Smart Manufacturing

Completed
Objective: The Digital Thread for Smart Manufacturing Systems project will deliver methods and protocols that extend and complete the digital thread for information running through design, manufacturing and product support processes to integrate smart manufacturing systems. The results of this

Digital Twins for Advanced Manufacturing

Ongoing
Objective To provide measurement science and open standards to help manufacturers better define, measure, analyze, and control advanced manufacturing systems using digital twins and enable a marketplace for digital twin users and technology providers. Technical Idea This Digital Twins for Advanced