The Organic Chemical Metrology Group (OCMG) develops, critically evaluates, and applies analytical methods based on liquid chromatography, gas chromatography, high-resolution mass spectrometry, multidimensional chromatographic separation procedures, vibrational and nuclear magnetic resonance spectroscopy, as related to analyses at trace and ultratrace concentration levels. The OCMG designs, produces and maintains an extensive portfolio of Standard Reference Materials and data products, primary standards, and Quality Assurance programs for organic species in clinical, nutritional assessment and metabolomics, food safety and nutrition, dietary supplement and natural products, chemical manufacturing, and forensics program areas. The group provides advice and measurement services to other government agencies, scientific organizations, and US industry; and engages with international standards organizations and other National Metrology Institutes (NMIs) to establish comparability of measurement capabilities.