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Young Jong Lee (Fed)
Research Chemist, Project Leader
Since Young Jong Lee joined NIST in 2006, he has developed new spectral imaging technologies based on coherent Raman scattering and infrared (IR) absorption. His recent research has focused on the development of the quantitative and structural measurement techniques for proteins, gene delivery systems, cells, polymer films, microplastics, and semiconductor packaging materials. (orcid.org/0000-0001-7754-3001).
CURRENT RESEARCH INTERESTS
Development of New Measurement Technology (listed from new to old in each category)
- High-sensitivity IR spectroscopy based on quantum cascade lasers (QCL)
- QCL-IR microscopy for quantitative imaging of biochemicals in live cells
- Quantitative imaging of microplastics with chemical identification
- 3D orientation imaging using polarization-controlled IR and BCARS microscopy
- Label-free chemical imaging by broadband coherent anti-Stokes Raman scattering (BCARS) microscopy
- Advanced analysis of complex spectra using 2-dimensional correlation spectroscopy (2DCOS)
Therapeutic Proteins
- Glycan and monosaccharide analysis of glycoproteins by QCL-IR spectroscopy
- Quantitative IR spectroscopy of proteins and gene delivery systems
- Biophysical stability (unfolding/aggregation) of protein drugs
Cell Systems and Tissues
- Label-free IR imaging of live cells and measuring absolute quantities of biomolecules per cell
- Optical and spectral measurement of cell viability and other cell statuses
Soft Matter Physics
- Spectral identification of microplastics
- Kinetics and imaging of molding materials for advanced packaging in CHIPS
- Molecular and orientational structure of polymer films
EMPLOYMENT OPPORTUNITIES
NRC Postdoctoral Fellowship: US citizens only. Please visit the following opportunities.
- Label-Free Cell Imaging Using Advanced Vibrational Spectroscopy
- Advanced Imaging of Biomaterials and Smart Polymers
- Advanced Vibrational Spectroscopy of Proteins
- Mapping Responses in Complex Microbial Systems using Advanced Imaging
We may have postdoc positions open to both non-US citizens and US citizens. If interested in any of the projects described above, please email Young Jong Lee at youngjong.lee [at] nist.gov (youngjong[dot]lee[at]nist[dot]gov).
Awards
- 2022: Department of Commerce Bronze Medal Award, “For the development of broadband coherent anti-Stokes Raman scattering microscopy for quantitative, comparable chemical imaging in complex samples.”
- 2013: MML Distinguished Associate Award for Technical Achievement, “For crucial innovations in the development and application of rapid data acquisition methods and reliable and reproducible data analysis in broadband coherent anti-Stokes Raman imaging.”
