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Agile Nucleic Acid Sensor And Measuring A Biomarker
Published Patent Application Number: 2022/0325332 A1
Abstract
An agile nucleic acid sensor includes: a DNA switch; an analysis substrate in electrostatic communication with the DNA switch and that produces a biomarker electrical signal; a transduction member that receives the biomarker electrical signal and produces a transduction signal; a sensor counter electrode in electrical communication with and capacitively coupled to the analysis substrate and that receives a counter electrode voltage; a sensor reference electrode in electrical communication and capacitively coupled to the analysis substrate and that produces a feedback signal based on electrical interactions with a composition that is in fluid contact with the feedback signal and the analysis substrate; and a voltage follower in electrical communication with the sensor counter electrode and the sensor reference electrode and that receives the feedback signal from the sensor reference electrode and produces the counter electrode voltage for the sensor counter electrode based on the feedback signal.