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PUBLICATIONS

Halothane Changes the Domain Structure of a Binary Lipid Membrane

Published

Author(s)

Michael Weinrich, Hirsh Nanda, David Worcester, Charles Majkrzak, Brian B. Maranville, Sergey M. Bezrukov

Abstract

X-ray and neutron diffraction studies of model lipid raft membranes demonstrate that halothane at physiological concnetrations produces redistribution of lipids between domains of different lipid types identified by different lamellar-d-spacings and isotope composition. In contrast, dichlorohexaflurocyclobutane, a fully halogenated non-anesthetic, does not produce significant phase redistribution. These finding demonstrate a specific effect of inhalational anesthetic on the mixing phase equilibria of complex lipid mixtures that mimic the complexity of real biological membranes.
Citation
Langmuir
Volume
28
Pub Type
Journals

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Keywords

Bilayer Membranes, Lipid Rafts, Lateral Phase Separation, Inhalation Anesthetics, Halothane, Neutron Diffraction, X-ray Diffraction

Citation

Weinrich, M. , Nanda, H. , Worcester, D. , Majkrzak, C. , Maranville, B. and Bezrukov, S. (2012), Halothane Changes the Domain Structure of a Binary Lipid Membrane, Langmuir, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=908734 (Accessed January 2, 2025)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created February 27, 2012, Updated October 12, 2021