Preparation and Comprehensive Characterization of a Calicum Hydroxyapatite Reference Material

Published

November 1, 2004

Author(s)

D W. Fowler, Milenko Markovic, Michael Tung

Abstract

Numerous biological and chemical studies involve the use of calcium hydroxyapatite Ca₁₀(PO₄)₆(OH)₂, HA. In this study detailed physicochemical characterization of HA prepared from an aqueous solution was carried out employing different methods and techniques: chemical and thermal analyses, X-ray diffraction, infrared and Raman spectroscopies, scanning and transmission microscopies and Brunauer, Emmett, and Teller (BET) surface-area method. The Ca, PO₄, OH, HPO₄, H₂O, CO₃, and trace constituent contents, the Ca/P molar ratio, crystal size and morphology, surface area, unit-cell parameters, crystallinity, and solubility of this HA were determined. This homogeneous, essentially pure and crystalline HA is certified as a National Institute of Standards and Technology (NIST) standard reference material (SRM 2910).

Citation

Journal of Research (NIST JRES) -

Volume

109 No. 6

NIST Pub Series

Journal of Research (NIST JRES)

Pub Type

NIST Pubs

Keywords

chemical analysis, crystal size, crystallinity, hydroxyapatite, infrared, morphology, preparation, Raman, surface area

Citation

Fowler, D. , Markovic, M. and Tung, M. (2004), Preparation and Comprehensive Characterization of a Calicum Hydroxyapatite Reference Material, Journal of Research (NIST JRES), National Institute of Standards and Technology, Gaithersburg, MD (Accessed January 15, 2025)