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AlphaFold3 (AF3), available as a webserver, predicts the structures of all life's biomolecules. We evaluate its accuracy for oligonucleotides via agreement with
Veronika Szalai, Christina Bergonzo, Rachel Lyon, Zvi Kelman, Thomas Schmidt, Alexander Grishaev
Antibody-based pharmaceuticals are the leading biologic drug platform ($50B/year). Despite a wealth of information collected on them, there is still a lack of
Harold Hatch, Christina Bergonzo, Marco Blanco, Guangcui Yuan, Sergei Grudinin, Mikael Lund, Joseph E. Curtis, Alexander Grishaev, Yun Liu, Vincent K. Shen
We develop a multiscale coarse-grain model of the NIST Monoclonal Antibody Reference Material 8671 (NISTmAb) to enable systematic computational investigations
Guangcui Yuan, Paul Salipante, Steven D. Hudson, Richard Gillilan, Qingqiu Huang, Harold Hatch, Vincent Shen, Alexander Grishaev, Suzette Pabit, Rahul Upadhya, Sudeep Adhikari, Jainik Panchal, Marco Blanco, Yun Liu
The solution viscosity and protein−protein interactions (PPIs) as a function of temperature (4−40 °C) were measured at a series of protein concentrations for a