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Darwin R. Reyes (Fed)

Project Leader/Biomedical Engineer

Dr. Darwin R. Reyes is a project leader in the Microsystems and Nanotechnology Division of the Physical Measurement Laboratory (PML) at the National Institute of Standards and Technology (NIST). He received a B.S. and Ph.D. in chemistry from the University of Puerto Rico, and an M.S. in Applied Biomedical Engineering from Johns Hopkins University. His research work spans from environmental analytical chemistry and toxicology during his Ph.D. to the development of microfluidic devices for two-dimensional separations and analog computing using glow discharge in microfluidic chips during his NSF postdoctoral fellowship at Imperial College, London, UK. While at NIST, Dr. Reyes’ research has focused on the development of tissue/organ-on-a-chip devices with integrated electronic and optical measurement tools to enable real-time Heart on a Chip and cancer cell-based testing for drug development and toxicity assays. Dr. Reyes is a Co-founder and Chair of the Microfluidics Association (MFA), an international standards development organization that fosters the development of ISO standards and guidelines for the microfluidics community. He is also the Chair of the International Micro Physiological Systems (IMPS) Society’s Standardization Interest Group, and the Co-Chair of the Organ/Tissue on a Chip Engineering and Efficacy Standardization Working Group. He recently was bestowed the PML/NIST Outstanding Achievement in Measurement Services and Standards Award for his contributions to the development of ISO standards through his work with the MFA.

CURRENT RESEARCH PROJECTS

BioMEMS PROJECT MEMBERS

Awards

PML/NIST Outstanding Achievement in Measurement Services and Standards Award

Selected Publications

Amontons-Coulomb-like slip dynamics in acousto-microfluidics

Author(s)
Aurore F. Quelennec, Jason J. Gorman, Darwin Reyes-Hernandez
Electroacoustic technologies, which employ acoustic waves to manipulate and detect bioparticles, have been increasingly used, with a great deal of success, in

Publications

Recommendations on fit-for-purpose criteria to establish a quality management for microphysiological systems (MPS) and for monitoring of their reproducibility

Author(s)
David Pamies, Jason Ekert, Marie-Gabrielle Zurich, Olivier Frey, Sophie Werner, MONICA PIERGIOVANNI, Benjamin Freedman, Adrian Keong, Darwin Reyes-Hernandez, Hendrik Erfurth, Peter Loskill, Pelin Candarlioglu, Shan Wang, Thomas Hartung, Sandra Coecke, Glyn Stacey, Marcel Leist
Cell culture technology has seen great innovations and progress in teh 21st centuryClassical single-cell and monolayer models have been replaced by more complex

Overcoming Technological Barriers in Microfluidics: Leakage Testing

Author(s)
Vania Silverio, Suvajyoti Guha, Armelle Keiser, Rucha Natu, Darwin Reyes-Hernandez, Henne van Heeren, Nicolas Verplanck, Luke Herbertson
The miniaturization of laboratory procedures for Lab-on-Chip (LoC) devices and translation to various platforms such as single cell analysis or Organ-on-Chip

Patents (2018-Present)

Duel Dielectropheretic Membrane for Monitoring Cell Migration

NIST Inventors
Darwin R. Reyes
A dual dielectropheretic article for monitoring cell migration includes: a membrane to selectively migrate a plurality of cells across the membrane, the membrane including: a first surface to receive the cells; a second surface opposed to the first surface; and a plurality of communication paths
Created April 29, 2019, Updated October 2, 2024