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Mandy Esch (Fed)
Mandy B. Esch is a project leader in the Microsystems and Nanotechnology Division. She received an M.S. in Biology and a Ph.D. in Biotechnology from the Julius Maximilians University in Würzburg, Germany. During her PhD research she developed paper-based microfluidics and microfluidic biosensors for the detection of pathogens. In 2001, Dr. Esch joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison. In 2007, she joined the department of Biomedical Engineering at Cornell University as a senior research associate. While there, she developed several patents for multi-organ body-on-a-chip systems. As part of a team that develops MPS systems, she received the 2015 Lush Science Prize. From 2015 to 2016 Dr. Esch spent a year as an assistant professor at Syracuse University at the Department of Biomedical and Chemical Engineering. She taught nanobiotechnology and built a laboratory for tissues-on-chip research. In August of 2016 Dr. Esch moved to NIST, where she is focusing on integrating sensors with tissues-on-a-chip and MPS devices.
NRC postdoc opportunities
We are looking for postdocs with expertise in the development of on organs-on-chips, MPS, and PBPK modelling. Please contact Dr. Esch via email, or read about the NRC opportunity here.
Selected Publications
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Body-in-a-cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate, Chen, L., Yang, Y., Ueno, H., and Esch, M. B., Microphysiological Systems 4, 1–13 (2020).
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A pumpless microfluidic device for long-term culture of primary human lymphatic endothelial cells under high shear, Fathi, P., Holland, G., Pan, D., and Esch, M.B., ACS Applied Biomaterials accepted September 7, 2020.
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Pumpless microfluidic devices for generating healthy and diseased endothelia Y. Yang, P. Fathi, G. Holland, D. Pan, N.S. Wang, M.B. Esch, Lab on a Chip 19 (19), 3212-3219
- Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue, M.B. Esch, H. Ueno, D.R. Applegate, M.L. Shuler, Lab on a Chip, 2016, 16 (14), 2719-2729.
- Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs, C. Oleaga, C. Bernabini, A.S.T. Smith, B. Srinivasan, M. Jackson, W. McLamb, V. Platt, R. Bridges, Y. Cai, N. Santhanam, B. Berry, S. Najjar, N. Akanda, X. Guo, C. Martin, G. Ekman, M. B. Esch, J. Langer, G. Ouedraogo, J. Cotovio, L. Breton, M. L. Shuler, J. J. Hickman, Scientific Reports, 2016, 6, 1-17.
- Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow, M.B. Esch, J.M. Prot, Y.I. Wang, P. Miller, J.R. Llamas-Vidales, B.A. Naughton, D. Applegate, M.L. Shuler, Lab on a Chip, 2015, 15 (10), 2269-2277.
- Endothelial retention and phenotype on carbonized cardiovascular implant surfaces, C.M. Frendl, S.M. Tucker, N.A. Khan, M.B. Esch, S. Kanduru, T.M. Cao, J. Butcher, Biomaterials, 2014, 35 (27), 7714-7723.
- How multi-organ microdevices can help foster drug development, M.B. Esch, A.S.T. Smith, J.M. Prot, C. Oleaga, J.J. Hickman, M.L. Shuler, Advanced Drug Delivery Reviews, 2014, 69, 158-169.
- Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury, M.B. Esch, G.J. Mahler, T. Stokol, M.L. Shuler, Lab on a Chip, 2014, 14 (16), 3081-3092.
- Microfabricated mammalian organ systems and their integration into models of whole animals and humans, J.H. Sung, M.B. Esch, J.M. Prot, C.J. Long, A. Smith, J.J. Hickman, M.L. Shuler, Lab on a Chip, 2013, 13 (7), 1201-1212.
- On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’devices, M.B. Esch, J.H. Sung, J. Yang, C. Yu, J. Yu, J.C. March, M.L. Shuler, Biomedical Microdevices, 2012, 14 (5), 895-906.
- Oral exposure to polystyrene nanoparticles affects iron absorption, G.J. Mahler, M.B. Esch, E. Tako, T.L. Southard, S.D. Archer, R.P. Glahn, M.L. Shuler, Nature Nanotechnology 7 (4), 264-271.
- Characterization of in vitro endothelial linings grown within microfluidic channels, M.B. Esch, D.J. Post, M.L. Shuler, T. Stokol, Tissue Engineering Part A, 2011, 17 (23-24), 2965-2971.
- The role of body-on-a-chip devices in drug and toxicity studies, M.B. Esch, T.L. King, M.L. Shuler, Annual Review of Biomedical Engineering, 2011 13, 55-72.