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Activity measurements and calibrations for 225Ac in radioactive equilibrium with its progeny

Published

Author(s)

Denis Bergeron, Gulakhshan Hamad, Brittany Broder, Jeffrey Cessna, Adam Pearce, Jerome LaRosa, Leticia Pibida, Brian E. Zimmerman

Abstract

The massic activity of 225Ac in 0.1 mol/L HCl was measured by multiple primary methods over four consistent measurement campaigns. Results from the triple-to-double coincidence ratio (TDCR) method of liquid scintillation (LS) counting were in accord with other LS-based primary methods. The calibration of commercial radionuclide calibrators ("dose calibrators") is described, with discussion of current literature values. Comparisons between experimental ionization chamber and NaI(Tl) well counter responses and benchmarked Monte Carlo models are addressed.
Citation
Applied Radiation and Isotopes
Volume
217

Keywords

Actinium-225, activity standard, liquid scintillation counting, TDCR, gamma-ray spectrometry, radionuclide calibrator, radiopharmaceutical therapy, targeted alpha therapy, long-lived impurities, breakthrough

Citation

Bergeron, D. , Hamad, G. , Broder, B. , Cessna, J. , Pearce, A. , LaRosa, J. , Pibida, L. and Zimmerman, B. (2024), Activity measurements and calibrations for 225Ac in radioactive equilibrium with its progeny, Applied Radiation and Isotopes, [online], https://doi.org/10.1016/j.apradiso.2024.111630, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=958355 (Accessed February 2, 2025)

Issues

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Created December 9, 2024, Updated December 16, 2024