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Analytical Gaps and Challenges for Particles in the Submicrometer Size Domain

Published

Author(s)

Scott Aldrich, Shawn Cao, Andrea Hawe, Desmond Hunt, Linda Narhi, Dean C. Ripple, Satish Singh

Abstract

This Stimuli article provides a technical discussion of the available technologies for submicrometer particle analysis, including consideration of the advantages, disadvantages, and technical gaps for each application. These methods can be used in the characterization of different protein aggregates as well as other types of particles in this size range. Changes are occurring rapidly in this field, so the article and discussions focus on measurement principles and comparisons rather than specific instruments.
Citation
Pharmacopeial Forum
Volume
42
Issue
6

Keywords

Biopharmaceutical, Light Scattering, Nanoparticle Tracking Analysis, Particles, Protein, Resonance Mass Measurement, Silicone Oil

Citation

Aldrich, S. , Cao, S. , Hawe, A. , Hunt, D. , Narhi, L. , Ripple, D. and Singh, S. (2016), Analytical Gaps and Challenges for Particles in the Submicrometer Size Domain, Pharmacopeial Forum, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=920268 (Accessed October 31, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created November 30, 2016, Updated October 13, 2022