Daniels, Y.
, MacCrehan, W.
, Muramoto, S.
, , G.
, Vodyanoy, V.
and Pustovyy, O.
(2016),
Engineered metal nanoparticles in the sub-nanomolar levels kill cancer cells, Nanomedicine: nanotechnology, biology, and medicine, [online], https://doi.org/10.2147/IJN.S101463
(Accessed November 24, 2024)
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Engineered metal nanoparticles in the sub-nanomolar levels kill cancer cells
Published
Author(s)
, , , , Vitaly Vodyanoy, Oleg Pustovyy
Abstract
Zinc and copper metal nanoparticles were produced from bulk metal rods by an underwater high-voltage discharge method. The metal nanoparticles, with estimated diameters of 1 nm to 2 nm, were determined to be more than 85 % non-oxidized. Exposure of rat RG2 glioma cancer cells to these nanoparticles resulted in morphological cell changes, including decreased cell adherence, shrinking/rounding, nuclear condensation and budding from cell bodies. The nanoparticles were lethal for the cells at the sub-nanomolar concentrations.Citation
Nanomedicine: nanotechnology, biology, and medicine
Volume
11
Pub Type
Journals
Download Paper
Keywords
nanoparticles, xps, glioma cancer cell, apoptosis
Citation
Issues
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Created April 18, 2016, Updated November 10, 2018