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PUBLICATIONS

Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity

Published

Author(s)

Sean Jollota, Denis E. Bergeron, R. Michael Verkouteren, Svetlana Nour, Ryan P. Fitzgerald, Ohyun Kwon, Jeffrey Radtke, Bryan Bednarz, Brian Miller, Larry DeWerd

Abstract

Autoradiography can be an important tool in preclinical investigations with alpha-emitting radionuclides. Precise biodistribution studies establish the effectiveness of chemical "targeting" strategies, assuring that the promise of targeted alpha therapy (TAT) is realized. There is a need for calibration and test objects (phantoms) to evaluate and support precise autoradiography. Leveraging recent advances in drop-on-demand inkjet methods, we demonstrate the preparation of an autoradiography phantom with activity traceable to primary measurements and spatial features resolved to less than 20 μm. Corrections required to calibrate a digital autoradiography system for activity are discussed.
Citation
Applied Radiation and Isotopes
Pub Type
Journals
Radiation, Precision medicine and Medical imaging

Citation

Jollota, S. , Bergeron, D. , Verkouteren, R. , Nour, S. , Fitzgerald, R. , Kwon, O. , Radtke, J. , Bednarz, B. , Miller, B. and DeWerd, L. (2024), Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity, Applied Radiation and Isotopes (Accessed November 23, 2024)

Issues

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Created October 8, 2024, Updated October 28, 2024