Jollota, S.
, Bergeron, D.
, Verkouteren, R.
, Nour, S.
, Fitzgerald, R.
, Kwon, O.
, Radtke, J.
, Bednarz, B.
, Miller, B.
and DeWerd, L.
(2024),
Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity, Applied Radiation and Isotopes, [online], https://doi.org/10.1016/j.apradiso.2025.111683, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=958460
(Accessed April 24, 2025)
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Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity
Published
Author(s)
, , , , , Ohyun Kwon, Jeffrey Radtke, Bryan Bednarz, Brian Miller, Larry DeWerd
Abstract
Autoradiography can be an important tool in preclinical investigations with alpha-emitting radionuclides. Precise biodistribution studies establish the effectiveness of chemical "targeting" strategies, assuring that the promise of targeted alpha therapy (TAT) is realized. There is a need for calibration and test objects (phantoms) to evaluate and support precise autoradiography. Leveraging recent advances in drop-on-demand inkjet methods, we demonstrate the preparation of an autoradiography phantom with activity traceable to primary measurements and spatial features resolved to less than 20 μm. Corrections required to calibrate a digital autoradiography system for activity are discussed.Citation
Applied Radiation and Isotopes
Volume
218
Pub Type
Journals
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Created October 7, 2024, Updated February 14, 2025