Kwon, I.
, Lee, J.
, Tokumasu, F.
, Lee, S.
and Hwang, J.
(2025),
PERSPECTIVE Hyperspectral analysis to assess gametocytogenesis stage progression in malaria-infected human erythrocytes, Journal of Biomedical Optics, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=958535
(Accessed March 12, 2025)
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PERSPECTIVE Hyperspectral analysis to assess gametocytogenesis stage progression in malaria-infected human erythrocytes
Published
Author(s)
Ik Hwan Kwon, Ji Youn Lee, Fuyuki Tokumasu, Sang Won Lee,
Abstract
Developments of anti-gametocyte drugs have been delayed due to insufficient understanding of gametocyte biology. We report a systematic workflow of data processing algorithms to quantify changes in the absorption spectrum and cell morphology of single malaria-infected erythrocytes. These changes may serve as biomarkers instrumental for the future development of antimalarial strategies, especially for anti-gametocyte drug design and testing. Image-based biomarkers may also be useful for nondestructive, label-free malaria detection and drug efficacy evaluation in resource-limited communities.Citation
Journal of Biomedical Optics
Volume
30
Issue
2
Pub Type
Journals
Download Paper
Keywords
malaria, plasmodium falciparum, erythrocyte, gametocytes, gametocytogenesis, hyperspectral imaging, spectral angle mapper, hemoglobin, hemozoin, supervised classification
Citation
Issues
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Created January 14, 2025, Updated February 27, 2025