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Search Publications

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Displaying 1 - 25 of 823

Feasibility of Metrological Traceability Implementation Using the Joint Committee on Traceability in Laboratory Medicine Database Entries Including the Fulfillment of "Fit-for-Purpose" Maximum Allowable Measurement Uncertainty

September 24, 2024
Author(s)
MAURO PANTEGHINI, Johanna Camara, VINCENT DELATOUR, Katleen Van Uytfanghe, Hubert Vesper, Tianjiao Zhang
Background: In previous publications, the Task Force on Reference Measurement System Implementation proposed a procedural approach combining a critical review of entries available in the Joint Committee on Traceability in Laboratory Medicine (JCTLM)

Bilirubin measurements in neonates: uniform neonatal treatment can only be achieved by improved standardization

July 26, 2024
Author(s)
Christian Hulzebos, Johanna Camara, Miranda van Berkel, VINCENT DELATOUR, Stanley Lo, Agnes Mailloux, Marcel Schmidt, Mercy Thomas, Lindsey Mackay, Ronda Greaves
Measurement of total serum bilirubin (TSB) concentration is the gold standard approach for diagnosing neonatal unconjugated hyperbilirubinemia. It is of utmost importance that the measured TSB concentration is sufficiently accurate to prevent

Morphologic alterations across three levels of biological organization following oral exposure to silver-polymer nanocomposites in Japanese medaka (Oryzias latipes)

July 5, 2024
Author(s)
Melissa Chernick, Alan Kennedy, Treye Thomas, Keana C. K. Scott, Joana Sipe, Christine Hendren, Mark Wiesner, David Hinton
Polymer nanocomposites have diverse industrial and commercial uses. While many toxicity studies have assessed the individual materials (e.g., polymer, nanomaterial) comprising nanocomposites, few have examined the potential toxicity of the nanocomposite as

Investigation of the effect of peptide p5 targeting CDK5-p25 hyperactivity on Munc18-1(P67) regulating neuronal exocytosis using molecular simulations

July 2, 2024
Author(s)
Tejaswi Tammareddy, Walid Keyrouz, Ram Sriram, Harish Pant, Antonio Cardone, Jeffery Kluada
Munc18–1 is an SM (sec1/munc-like) family protein involved in vesicle fusion and neuronal exocytosis. Munc18–1 is known to regulate the exocytosis process by binding with closed- and open-state conformations of Syntaxin1, a protein belonging to the SNARE

Fully integrated multifunctional sensor and open-source ASIC for flexible wearables

June 25, 2024
Author(s)
Anhang Li, Hongyi Wu, Ashbir Aviat Fadila, Chanho Kye, Arvind Balijepalli, Johan Euphrosine, Tim Ansell, Nigel Coburn, Sachin Nadig, Mehdi Saligane
The open-source hardware movement has made significant progress over the past few years. Increasingly, more individuals are engaging with and participating in the open-source chip design community - not only to design their own chips with the available

Identification of Candidate Protein Biomarkers Associated with Domoic Acid Toxicosis in Cerebrospinal Fluid of California Sea Lions (Zalophus californianus)

May 28, 2024
Author(s)
Gautam Ghosh, Ben Neely, Alison Bland, Emily Whitmer, Cara Field, Padraig Duignan, Michael Janech
Since 1998, California sea lion (Zalophus californianus) stranding events associated with domoic acid toxicosis have consistently increased. Currently there are no practical non-lethal clinical tests for the diagnosis of domoic acid toxicosis (DAT) that

Standards and Metrology for Viral Vectors as Molecular Tools: Outcomes from a CCQM Workshop

May 24, 2024
Author(s)
Janathan Campbell, Neil Almond, Y Bae, Ravneet Bhuller, Andrea Briones, S-Y CHO, Megan Cleveland, Thomas Cleveland, Francis Galaway, Hua-Jun He, U Herbrand, Jim Huggett, Sarah Kempster, Ibolya Kepiro, Afifa Khan, Edward Kwee, Wilson Li, Sheng Lin-Gibson, Luise Luckau, Caterina Minelli, M Ryadnov, I Searing, Lili Wang, Alexandra Whale, Julian Braybrook
Viral vectors are agents enabling gene transfer and genome editing and have widespread utility across the healthcare and biotechnology sectors. In January 2023, the International Bureau for Weights and Measures' Consultative Committee for Amount of

Ensuring accuracy in the development and application of nucleic acid amplification tests (NAATs) for infectious disease

May 20, 2024
Author(s)
Jim Huggett, Denise O'Sullivan, Simon Cowen, Megan Cleveland, Jacob Moran-Gilad, Amanda Winter, Michael Messenger, Julian Braybrook
Diagnostic tests were heralded as crucial during the COVID-19 pandemic with most of the key methods using bioanalytical approaches. Bioanalytical techniques can be loosely described as methods that identify and quantify larger molecules (than conventional

Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-well Plate System Using Electron Paramagnetic Resonance Oxygen Imaging

May 1, 2024
Author(s)
Safa Hameed, Navin Viswakarma, Eliyas Siddiqui, Greta Babakhanova, Carl Simon Jr., Boris Epel, Mrignayani Kotecha
Cell viability is an essential measurement for cell therapy, tissue engineered medical products (TEMPs), drug development, and many other biological processes and products. These systems rely on viable, healthy, and functional cells to work as intended

Spatial Variation in Mercury Accumulation in Bottlenose Dolphins (Tursiops spp.) in Southeastern U.S.A.

April 30, 2024
Author(s)
Mackenzie Griffen, Colleen E. Bryan Sallee, Tara Cox, Brian Balmer, Russell Day, Laura Garcia Barcia, Antoinette Gorgone, Jeremy Kiszka, Jenny Litz, Robin Perrtree, Teri Rowles, Lori Schwacke, Randall Wells, Eric Zolman
Bottlenose dolphins (Tursiops spp.) inhabit bays, sounds, and estuaries (BSEs) throughout the southeast region of the U.S.A. and are sentinel species for human and ecosystem-level health. Dolphins are vulnerable to the bioaccumulation of contaminants

A Four-Grating Interferometer for X-Ray Multi-Contrast Imaging

March 24, 2024
Author(s)
Daniel Josell, Houxun Miao, James Williams, Jr.
Background: X-Ray multi-contrast imaging with gratings provides a practical method to detect the differential phase and dark-field contrast images in addition to the traditional X-ray absorption image in a laboratory or hospital environment. Systems have

Heart-on-a-Chip Systems: Disease Modeling and Drug Screening Applications

February 14, 2024
Author(s)
Derrick Butler, Darwin Reyes-Hernandez
Cardiovascular disease (CVD) is the leading cause of death worldwide, casting a substantial economic footprint and burdening the global healthcare system. Historically, pre-clinical CVD modeling and therapeutic screening has been performed using animal

Cybersecurity of Genomic Data

December 20, 2023
Author(s)
Ronald Pulivarti, Natalia Martin, Frederick R. Byers, Justin Wagner, Justin Zook, Samantha Maragh, Jennifer McDaniel, Kevin Wilson, Martin Wojtyniak, Brett Kreider, Ann-Marie France, Sallie Edwards, Tommy Morris, Jared Sheldon, Scott Ross, Phillip Whitlow
Genomic data has enabled the rapid growth of the U.S. bioeconomy and is valuable to the individual, industry, and government because it has multiple intrinsic properties that in combination make it different from other types of high value data which

Spatially-Dependent Model for Rods and Cones in the Retina

December 14, 2023
Author(s)
Daniel M. Anderson, Danielle Brager, Anthony J. Kearsley
We develop a mathematical model for photoreceptors in the retina. We focus on rod and cone outer segment dynamics and interactions with a nutrient source associated with the retinal pigment epithelium cells. Rod and cone densities (number per unit area of

Microfluidic Blood Separation: Key Technologies and Critical Figures of Merit

November 18, 2023
Author(s)
Karina Torres Castro, Katherine Acuna-Umana, Leonardo Lesser-Rojas, Darwin Reyes-Hernandez
Blood is a complex sample comprised mostly of plasma, red blood cells (RBCs), and other cells whose concentrations correlate to physiological or pathological health conditions. There are also many blood-circulating biomarkers, such as circulating tumor

Recommendations for setting a criterion and assessing commutability of sample materials used in external quality assessment/proficiency testing schemes

November 2, 2023
Author(s)
Sverre Sandberg, Pernille Fauskanger, Jesper Johansen, Thomas Keller, Jeffrey Budd, Neil Greenberg, robert rej, MAURO PANTEGHINI, VINCENT DELATOUR, Ferruccio Ceriotti, Liesbet Deprez, Johanna Camara, Finlay MacKenzie, Alicia Lyle, Eline van der Hagen, Chris Burns, W. Greg Miller
It is important for external quality assessment materials (EQAMs) to be commutable with clinical samples; i.e., they should behave like clinical samples when measured using end-user clinical laboratory in vitro diagnostic medical devices (IVD-MDs). Using

Evaluation of 3D Curvature and Lead Stress of Transvenous Right Ventricular Leads: The Human Use Conditions Study (HUCS)

September 9, 2023
Author(s)
Jonathan Piccini, Tim Quinn, Lucas Koepke, James Dawson, Nicki Mara, Jason Santelli, Diane Muff, Jordan Savela, Alex Felber, Michael Friedrich, Jens Rump, Felix Tschentscher, Jake Benzing, Charles Swerdlow
Transvenous leads of cardiac implanted electronic device (CIED) systems are meant to last the life of the patient, but they are at risk for conductor fatigue fracture from applied alternating stress. This stress depends on lead design and use conditions
Displaying 1 - 25 of 823