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Search Publications by: Donald H. Atha (Assoc)

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Displaying 1 - 25 of 72

Renewable Standard Reference Material for the Detection of TP53 Mutations

October 12, 2021
Author(s)
C D. O'Connell, L A. Tully, J E. Devaney, M A. Marino, J P. Jakupciak, Donald H. Atha
It is important to have standards for use in mutation detection systems to monitor the sensitivity of mutation detection and the possible introduction of errors during amplification and separation procedures. We have developed 12 plasmid clones containing

Controlled Potential Electrooxidation of Genomic DNA

January 11, 2018
Author(s)
Vytautas Reipa, Donald H. Atha, Sanem Hosbas Coskun, Christopher M. Sims, Bryant C. Nelson
Exposure of mammalian cells to oxidative stress can result in DNA damage that adversely affects many cell processes. We used bulk electrolysis in an electrochemical system and gas chromatographic mass spectrometric analysis (GC/MS/MS) to control and

The Comet Assay: Methods for Quantitative Image Analysis and Reproducibility

September 1, 2016
Author(s)
Donald H. Atha, Signe Braafladt, Vytautas Reipa
The comet assay,or single cell gel electrophoresis,is a sensitive and efficient technique for analyzing DNA damage in the form of single and double strand breaks in single cells. DNA alteration,from strand breaks,can lead to cancer and other health risks

Functionalization-Dependent Induction of Cellular Survival Pathways by CdSe Quantum Dots in Primary Normal Human Bronchial Epithelial Cells

September 5, 2013
Author(s)
Amber Nagy, Jennifer A. Hollingsworth, Bin Hu, Andrea Steinbruck, Peter C. Stark, Cristina Rios Valdez, Momchilo Vuyisich, Michael H. Stewart, Donald H. Atha, Bryant C. Nelson, Rashi Iyer
Quantum dots (QDs) are semiconductor nanocrystals exhibiting unique optical properties which can be exploited for many practical applications ranging from photovoltaics to biomedical imaging and drug delivery. They are increasingly manufactured in large

NIST Gold Nanoparticle Reference Materials Do Not Induce Oxidative DNA Damage

February 1, 2013
Author(s)
Bryant C. Nelson, Donald H. Atha, John T. Elliott, Bryce J. Marquis, Elijah J. Petersen, Danielle Cleveland, Stephanie S. Watson, I-Hsiang Tseng, Andrew Dillon, Melissa Theodore, Joany Jackman
Well-characterized, nanoparticle reference materials are urgently needed for nanomaterial toxicity studies. The National Institute of Standards and Technology has developed three gold nanoparticle (AuNP) reference materials (10 nm, 30 nm, 60 nm) to address

Copper oxide nanoparticle mediated DNA damage in terrestrial plant models

December 22, 2011
Author(s)
Bryant C. Nelson, Donald H. Atha, Elijah J. Petersen, Huanhua Wang, Danielle Cleveland, Richard D. Holbrook, Pawel Jaruga, M Miral Dizdar, Baoshan Xing
Engineered nanoparticles, due to their unique electrical, mechanical and catalytic properties, are presently found in many commercial products and will be intentionally or inadvertently released at increasing concentrations into the natural environment

Cellular DNA Biomarkers for the Safety of Tissue-Engineered Medical Products Using Artificial Skin as a Model

October 16, 2008
Author(s)
H Rodriguez, C D. O'Connell, Peter E. Barker, M. Dizdaroglu, Donald H. Atha, Pawel Jaruga, M Birincioglu, M A. Marino, P McAndrew
Fundamental to the safety of many tissue-engineered medical products is how cells respond to a given polymer when implanted into the body. Assurance of cellular stability during the manufacturing, storage and shipment of such products is crucial to achieve