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Search Publications by: Richard E Cavicchi (Fed)

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Displaying 1 - 25 of 171

Measuring the size of oil droplets in a flow cytometer using Mie Resonances

January 21, 2025
Author(s)
Richard E. Cavicchi, Dean Ripple, Joshua Welsh, Jerilyn Izac, Alexander Peterson, Aaron Goldfain, Wyatt N. Vreeland
An emulsion of silicone oil droplets in aqueous buffer produces a distinctive series of peaks or resonances in the side scatter histogram in a flow cytometer. As many as 12 peaks are observed in the violet-side scatter channel at 405 nm, with half that

Distribution of Average Aggregate Density from Stir-stressed NISTmAb Protein

March 19, 2022
Author(s)
Richard E. Cavicchi, Laura Philips, Fook Cheong, David Ruffner, Priya Kasimbeg, Wyatt N. Vreeland
Quantifying the heterogeneous nature of protein aggregates is important to understanding the impact aggregates may have on the performance of antibody therapeutics. The spatially averaged density p of aggregates, defined as the total mass, including water

Phase-Appropriate Application of Analytical Methods to Monitor Subvisible Particles Across the Biotherapeutic Drug Product Life Cycle

October 30, 2019
Author(s)
Roman Mathaes, Linda Narhi, Andrea Hawe, Anja Matter, Karoline Bechtold-Peters, Sophia Kenrick, Sambit Kar, Olga Laskina, John Carpenter, Richard E. Cavicchi, Ellen Koepf, Neil Lewis, Rukman De Sliva, Dean C. Ripple
The phase-appropriate application of analytical methods to characterize, monitor, and control particles is an important aspect of the development of safe and efficacious biotherapeutics. The AAPS Product Attribute and Biological Consequences (PABC) focus

Initiation of flash boiling of multicomponent miscible mixtures with application to transportation fuels and their surrogates

August 16, 2018
Author(s)
Charles T. Avedisian, Kyle Skyllingstad1, Richard E. Cavicchi, Corinne Lippe, Michael J. Carrier
This paper presents methodologies to predict thermodynamic conditions that initiate flash boiling by spontaneous nucleation of liquids consisting of hundreds of miscible liquids and their lower order surrogate mixtures. The methods are illustrated with a

Rapid Detection of Thin-Film Interfacial Reactions by MEMS-DSC

February 19, 2017
Author(s)
Lawrence P. Cook, Richard E. Cavicchi, Yanbao Zhang, Mark D. Vaudin, Christopher B. Montgomery, William F. Egelhoff Jr., Martin L. Green, Leslie Allen
A MEMS-based differential scanning calorimeter (DSC) has been used to characterize the Ni/Si interfacial reaction in thin films at ramp rates of 940 C/s and 3760 C/s. The DSC devices were fabricated using CMOS semiconductor processing technology, and were

Variable Threshold Method for Determining the Boundaries of Imaged Subvisible Particles

February 15, 2017
Author(s)
Richard E. Cavicchi, Cayla Collett, Srivalli Telikepalli, Zhishang Hu, Michael J. Carrier, Dean C. Ripple
An accurate assessment of particle characteristics and concentrations in pharmaceutical products by flow imaging requires accurate particle sizing and morphological analysis. Analysis of images begins with the definition of particle boundaries from the

Rapid evaporation at the superheat limit of methanol, ethanol, butanol and n-heptane on platinum films supported by low-stress SiN membranes

June 7, 2016
Author(s)
Eric J. Ching, C. T. Avedisian, Richard E. Cavicchi, Do H. Chung, Jeff Rah, Michael J. Carrier
The bubble nucleation temperatures of several organic liquids (methanol, ethanol, butanol,n-heptane) on stress-minimized platinum (Pt) films supported by SiN membranes is examined by pulse-heating the membranes for times ranging from 1 υs to 10 υs. The

Bubble Nucleation of Highly Superheated Water on Thin Film Platinum Films supported by SiN Membranes using a Low-Noise Bridge Circuit

December 1, 2014
Author(s)
Eric J. Ching, Michael J. Carrier, C. T. Avedisian, James R. Young, Bruce R. Land, Richard E. Cavicchi
This study describes the use of stress-minimized thin film platinum (Pt) membrane configurations (200 nm thick, 150 μm long, 10 μm wide) for promoting bubble nucleation of water near its superheat limit. The membrane designs consist of Pt films deposited