U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Search Publications by: Anthony J. Kearsley (Fed)

Search Title, Abstract, Conference, Citation, Keyword or Author
Displaying 26 - 50 of 151

Smoothing Techniques in Dynamic Building System Simulation

August 27, 2021
Author(s)
Zhelun Chen, Jin Wen, Anthony J. Kearsley, Amanda Pertzborn
Efficiently, robustly, and accurately solving systems of nonlinear differential algebraic equations (DAE) for dynamic building system simulation is becoming more important due to the increasing demand to simulate large-scale problems including the

CD19 Expression Analysis Using Two Flow cytometric Quantitative Schemes: An approach for Identifying Robust B-cell Reference Control Materials

March 19, 2021
Author(s)
Hao-Wei Wang, Paul Patrone, Anthony Kearsley, Jessica Watson, Liang Lim, Jothir Pichaandi, Olga Ornatsky, Daniel Majonis, Rukmini Bhardwaj, Howard Mostowski, Steven Bauer, Heba Degheidy, Lili Wang
Cell-based therapies have emerged as a novel approach to treat cancer and other conditions. Quantitative flow cytometry plays an increasingly important role in predicting therapy outcome in a wide range of hematologic malignancies. Several studies

Measurement of serological and neutralizing antibodies specific to SARS-CoV-2 virus in humans with COVID-19 disease

March 8, 2021
Author(s)
Linhua Tian, Elzafir B. Elsheikh, Paul Patrone, Anthony Kearsley, adolfas Gaigalas, Sarah L. Inwood, Sheng Lin-Gibson, Dominic Esposito, Lili Wang
The global response to COVID-19 has led to rapid advances in diagnostic, surveillance, and vaccine development. Critical measurements underpinning many of these efforts include serological assays to assess seroprevalence of populations and the complex

Failure mechanisms in DNA self-assembly: Barriers to single fold yield

February 23, 2021
Author(s)
Jacob Majikes, Paul Patrone, Anthony J. Kearsley, Michael P. Zwolak, James Liddle
Understanding the folding process of DNA origami is a critical steppingstone to the broader implementation of nucleic acid nanofabrication technology but is notably non-trivial. Origami are formed by several hundred cooperative hybridization events – folds

DYNAMIC MEASUREMENT OF NANOLITER PER MINUTE FLOW BY SCALED DOSAGE OF FLUORESCENT SOLUTIONS

October 3, 2020
Author(s)
Gregory A. Cooksey, Paul Patrone, James R. Hands, Stephen E. Meek, Anthony J. Kearsley
This work describes a new method for continuous measurement of flow in a microchannel from 1 nL/min to 1000 nL/min using an optofluidic device with waveguides that deliver and collect light from small regions of a microfluidic channel. By relating the

Diffusion-limited reactions in nanoscale electronics

September 22, 2020
Author(s)
Ryan Evans, Arvind Balijepalli, Anthony J. Kearsley
To quantify interactions between drug molecules and target receptors, a novel nanoscale electronics instrument is under development. The instrument consists of two regions: a biological region, and an electronics region. The biological region consists of a

Measuring Microfluidic Flow Rates: Monotonicity, Convexity and Uncertainty

August 20, 2020
Author(s)
Paul Patrone, Qing Hai Li, Gregory A. Cooksey, Anthony J. Kearsley
A class of non-linear integro-differential equations characterizing microfluidic measurements is considered. Under reasonable conditions, these non-linear integro-differential equations admit solutions that are convex functions of an interesting flow-rate

Revealing thermodynamics of DNA origami folding via affine transformations

June 4, 2020
Author(s)
Jacob M. Majikes, Paul N. Patrone, Daniel R. Schiffels, Michael P. Zwolak, Anthony J. Kearsley, Samuel P. Forry, James A. Liddle
Structural DNA nanotechnology, as exemplified by DNA origami, has enabled the design and construction of molecularly precise objects for a myriad of applications. However, limitations in imaging, and other characterization approaches, make a quantitative