U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Search Publications by: Susan Krueger (Assoc)

Search Title, Abstract, Conference, Citation, Keyword or Author
Displaying 1 - 25 of 53

Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

January 16, 2024
Author(s)
Jacob Thelen, Wellington Leite, Volker Urban, Hugh O'Neill, Alexander Grieshaev, Joseph E. Curtis, Susan N. Krueger, Maria M. Castellanos
The mRNA technology has emerged as a rapid modality to develop vaccines during pandemic situations with the potential to protect against endemic diseases. The success of mRNA in producing an antigen is dependent on the ability to deliver mRNA to the cells

A Round-Robin Approach Provides a Detailed Assessment of Biomolecular Small-Angle Scattering Data Reproducibility and Yields Consensus Curves for Benchmarking.

November 1, 2022
Author(s)
Jill Trewhella, Patrice Vachette, Jan Bierma, Clement Blanchet, Emre Brookes, Srinivas Chakravarthy, Leonie Chatzimagas, Thomas Cleveland, Nathan Cowieson, Ben Crossett, Anthony P. Duff, Daniel Franke, Frank Gabel, Richard E. Gillilan, Melissa Graewert, Alexander Grishaev, Jules M. Guss, Michal Hammel, Jesse Hopkins, Qingqui Huang, Jochen S. Hub, Gregory L. Hura, Thomas C. Irving, Cy M. Jeffries, Cheol Jeong, Nigel Kirby, Susan N. Krueger, Anne Martel, Tsutomu Matsui, Na Li, Javier Perez, Lionel Porcar, Thierry Prange, Ivan Rajkovic, Mattia Rocco, Daniel J. Rosenberg, Timothy M. Ryan, Soenke Seifert, Hiroshi Sekiguchi, Dmitri Svergun, Susana C. Marujo Teixeira, Aurelien Thureau, Thomas M. Weiss, Andrew Whitten, Kathleen Wood, Xiaobing Zuo
Small-Angle Scattering (SAS) data from 5 candidate proteins (RNaseA, lysozyme, xylanase, urate oxidase and xylose isomerase) were measured on 12 Small-Angle X-ray Scattering (SAXS) and 4 Small-Angle Neutron Scattering (SANS) instruments. In total, more

Structures and Dynamics of Anionic Lipoprotein Nanodiscs

April 21, 2022
Author(s)
D. Sweeney, Susan T. Krueger, Kakali Sen, John Hackett
Nanolipoprotein particles known as nanodiscs (NDs) have emerged as versatile and powerful tools for the stabilization of mem-brane proteins permitting a plethora of structural and biophysical studies. Part of their allure is their flexibility to

Head on Comparison of Self- and Nano-Assemblies of Gamma Peptide Nucleic Acid Amphiphiles

February 9, 2022
Author(s)
Shipra Malik, Vikas Kumar, Chung-Hao Liu, Kuo-Chih Shih, Susan T. Krueger, Mu-Ping Neih, Raman Bahal
Peptide nucleic acids (PNAs) are nucleic acid analogs with superior hybridization properties and enzymatic stability than deoxyribonucleic acid (DNA). In addition to gene targeting applications, PNAs have garnered significant attention as bio-polymer due

Specific DNA Binding to CRP Induces Conformational Changes in the CRP and the DNA in Solution: A Small-Angle Neutron Scattering Study

October 12, 2021
Author(s)
Susan T. Krueger, S. K. Gregurick, Y. Shi, S. Wang, B Waldkowski, Frederick P. Schwarz
The transcription activator, 3'-5' cyclic adenosine monophosphate (cAMP) receptor protein (CRP), when ligated with cAMP, activates the transcription of over 25 operons, which code for enzymes involved in carbohydrate metabolism in E. coli. Small-angle

Structural Characterization and Modeling of a Respiratory Syncytial Virus Fusion Glycoprotein Nanoparticle Vaccine in Solution

January 4, 2021
Author(s)
Susan T. Krueger, Joseph E. Curtis, Daniel R. Scott, Alexander Grishaev, Greg Glenn, Gale Smith, Larry Ellingsworth, Oleg Borisov, Ernest Maynard
Globally, respiratory syncytial virus (RSV)is a major cause of sever lower respiratory tract infection in young children, older adults, and immune compromised populations, for which there are no licensed vaccines. The RSV fusion (F)/polysorbate 80 (PS80)

SurA is a Cryptically Grooved Chaperone that Expands Unfolded Outer Membrane Proteins

October 21, 2020
Author(s)
Dagan C. Marx, Ashlee M. Plummer, Anneliese M. Faustino, Taylor Devlin, Michaela A. Roskopf, Mathis J. Leblanc, Henry J. Lessen, Barbara T. Amann, Patrick J. Fleming, Susan T. Krueger, Stephen D. Fried, Karen G. Fleming
The periplasmic chaperone network ensures the biogenesis of bacterial outer membrane proteins (OMPs) and has recently been identified as a promising target for antibiotics. SurA is the most important member of this network, both due to its genetic

Domain Interactions Determine the Conformational Ensemble of the Periplasmic Chaperone SurA

October 1, 2020
Author(s)
Dagan C. Marx, Mathis J. Leblanc, Ashlee M. Plummer, Susan T. Krueger, Karen G. Fleming
SurA is thought to be the most important periplasmic chaperone for outer membrane protein biogenesis. Its structure is composed of a core region and two peptidylprolyl isomerase domains, termed P1 and P2, connected by flexible linkers. As such these three

Characterization of an Extensive Interface on Vitronectin for Binding to Plasminogen Activator Inhibitor-1: Adoption of Structure in an Intrinsically Disordered Region

December 24, 2019
Author(s)
Letitia O. Puster, Christopher B. Stanley, Vladmir N. Uversky, Joseph E. Curtis, Susan T. Krueger, Yuzhuo Chu, Cynthia B. Peterson
Small-angle neutron scattering (SANS) measurements were used to characterize vitronectin, a protein found in human plasma and tissues that functions in regulating cell adhesion and migration, as well as proteolytic cascades that affect blood coagulation

ROTDIF-web and ALTENS: GenApp-based Science Gateways for Biomolecular Nuclear Magnetic Resonance (NMR) Data Analysis and Structure Modeling

September 23, 2019
Author(s)
Yuexi Chen, Cheol Jeong, Alexey Savelyev, Susan T. Krueger, Joseph E. Curtis, Emre H. Brookes, David Fushman
Proteins and nucleic acids participate in essentially every biochemical process in living organisms, and the elucidation of their structure and motions is essential for our understanding how these molecular machines perform their function. Nuclear Magnetic

Understanding the Static Interfacial Polymer Layer by Exploring the Dispersion States of Nanocomposites

May 5, 2019
Author(s)
Anne-Caroline Genix, Vera Bocharova, Bobby Carroll, Michelle Lehmann, Tomonori Saito, Susan T. Krueger, Lilin He, Philippe Dieudonne-George, Alexei P. Sokolov, Julian Oberdisse
The dynamic and static properties of the interfacial region between polymer and nanoparticles have wide-ranging consequences on performances of nanomaterials. The thickness and density of the static layer are particularly difficult to assess experimentally

Neutron Scattering in the Biological Sciences: Progress and Prospects

December 1, 2018
Author(s)
Rana Ashkar, Hassina Z. Bilheux, Heliosa Bordallo, Robert Briber, David J. E. Callaway, Xiaolin Cheng, Xiang-Qiang Chu, Joseph E. Curtis, Mark Dadmun, Paul Fenimore, David Fushman, Frank Gabel, Kushol Gupta, Frederick Herberle, Frank Heinrich, Liang Hong, John Katsaras, Zvi Kelman, Eugenia Kharlampieva, Gerald R. Kneller, Andrey Kovalevsky, Susan T. Krueger, Paul Langan, Raquel Lieberman, Yun Liu, Mathias Losche, Edward Lyman, Yimin NMN Mao, John Marino, Carla Mattos, Flora Meilleur, Peter Moody, Jonathan D. Nickels, William B. O'Dell, Hugh O'Neill, Ursula Perez-Salas, Judith Peters, Loukas Petridis, Alexei P. Sokolov, Robert Sutherland, Norman Wagner, Michael NMN Weinrich, Kevin Weiss, Troy Wymore, Yang Zhang, Jeremy C. Smith
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple scales of length and time. Pursuant to an NSF-funded workshop in February 2018, we review recent developments in this field as

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

December 5, 2017
Author(s)
Mark A. Nakasone, Timothy A. Lewis, Olivier Walker, Anita Thakur, Wissam Mansour, Carlos A. Castaneda, Jennifer L. Goeckeler-Fried, Frank Parlati, Tsui-Fen Chou, Ortal Hayat, Daoning Zhang, Christina M. Camara, Steven M. Bonn, Urszula K. Nowicka, Susan T. Krueger, Michael H. Glickman, Jeffrey L. Brodsky, Raymond J. Deshaies, David Fushman
The success of proteasome inhibitors has led to intense efforts to discover points of therapeutic intervention for nearly every component of the ubiquitin-proteasome system. The discovery of ubistatins, small molecules that inhibit proteasomal degradation