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Search Publications by: Joy Dunkers (Fed)

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Displaying 26 - 50 of 101

Analyses of a Cantilever-Beam Based Instrument for Evaluating the Development of Polymerization Stresses

August 9, 2011
Author(s)
Martin Chiang, Anthony A. Giuseppetti, Joy Dunkers, Jing Qian, Sheng Lin-Gibson, Gary E. Schumacher, Joseph M. Antonucci
Analytical and finite element analyses have been performed on a cantilever-beam based methodology (tensometer) for evaluating the development of stresses as the concomitant of constrained polymerization shrinkage. A guideline for designing a tensometer

Development of Probe Free Mapping of Cell Viability in Hydrogels

April 16, 2011
Author(s)
Joy P. Dunkers, Kaushik Chatterjee, Carl G. Simon Jr.
Diffusion of oxygen in cell/scaffold construct interior is of critical importance to cell viability in constructs of clinically relevant sizes. It has been shown that depletion of oxygen within the scaffold leads to a decrease in cell density and viability

Differences in Polydimethylsiloxane Modification Methods Affect Laminin Deposition and Smooth Muscle Cell Proliferation

April 13, 2011
Author(s)
Joy P. Dunkers, Hae-Jeong Lee, Marvi Matos, Lisa Pakstis, Juan M. Taboas, Steven D. Hudson, Marcus T. Cicerone
When culturing cells on flexible surfaces, it is important to consider extracellular matrix treatments that will remain on the surface under mechanical strain. Here we investigate differences in laminin surfaces that were deposited on oxidized PDMS (plasma

Solutions for Determining Equibiaxial Substrate Strain for Dynamic Cell Culture

May 2, 2010
Author(s)
Martin Y. Chiang, Tianle Cheng, Lisa Pakstis, Joy P. Dunkers
Empirical and analytical solutions are derived in this study to determine the equibiaxial strain on a flexible substrate upon which the cells can be cultured. The empirical formula is based on the mechanistic constraint and a regression analysis of results

Differences in PDMS Modification Affect Laminin Deposition and Smooth Muscle Cell Response

August 16, 2009
Author(s)
Joy P. Dunkers, Hae-Jeong Lee, Marvi Matos, Lisa Pakstis, Juan M. Taboas, Steven D. Hudson, Marcus T. Cicerone
When culturing cells on flexible surfaces, it is important to consider extracellular matrix treatments that will remain on the surface under mechanical strain. Here we investigate differences in laminin surfaces that were deposited on oxidized PDMS (plasma

Evaluation of Polydimethylsiloxane Modification Methods for Cell Response

February 20, 2009
Author(s)
Lisa Pakstis, Alan Zheng, Theodore V. Vorburger, Joy P. Dunkers, Timothy P. Quinn, Marcus T. Cicerone
Many methods exist in the literature to modify surfaces with extracellular matrix (ECM) proteins prior to cell attachment. However, there are few studies that systematically compare surface characterization and cell response results among different

Extending Measurement Science to Interactive Visualization Environments

January 30, 2009
Author(s)
Judith E. Terrill, William L. George, Terence J. Griffin, John G. Hagedorn, John T. Kelso, Thomas M. Olano, Adele P. Peskin, Steven G. Satterfield, James S. Sims, Jeffrey W. Bullard, Joy P. Dunkers, Nicos Martys, Agnes A. O'Gallagher, Gillian Haemer
We describe a method for creating a visual laboratory to interactively measure and analyze scientific data. We move the normal activities that scientists perform to understand their data into the visualization environment. The visualization environment is

Characterization of Laminin on Silanized Polydimethylsiloxane

August 21, 2008
Author(s)
Joy P. Dunkers, Lisa M. Hughes, Hae-Jeong Lee, Marvi Matos, Marcus T. Cicerone
In this work, we characterize a protein surface on a flexible polydimethylsiloxane substrate (PDMS) capable of undergoing strain. We compare the results from two different surface treatments: physically adsorbed laminin on PDMS and laminin deposited on

Methodology for Evaluating Candidate Geometric Reference Scaffolds

November 1, 2007
Author(s)
Joy P. Dunkers, Stefan D. Leigh, David Dean, M Cooke, Richard Ketcham, Marcus T. Cicerone
The motivation for the work is to rank candidate reference scaffolds by quality metrics in a systematic and quantitative manner by screening several microstructural descriptors of importance. We chose total pore volume, pore volume distribution, and pore

Investigation of 3D Tyrosine-Derived Polycarbonate Scaffold for Tissue Engineering

August 25, 2005
Author(s)
J S. Stephens, Tithi Dutta Roy, Joy P. Dunkers, Aarti Rege, J Kohn
A library of tyrosine-derived polycarbonates of have been developed that share a structurally identical backbone with a rich chemical and structural diversity, which depend solely on the pendent ester substituent (Scheme 1).1 The physical and chemical