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Search Publications by: Karen W. Phinney (Fed)

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Displaying 26 - 50 of 187

State-of-the-art and trends for the SI traceable value assignment of the purity of peptides using the model compound angiotensin I

March 27, 2018
Author(s)
Ralf D. Josephs, Norbert Stoppacher, Adeline Daireaux, Tiphaine Choteau, Katrice Lippa, Karen W. Phinney, Steven Westwood, Robert Wielgosz
Accurate diagnosis, monitoring and treatment are cornerstones of a healthcare system and require reliable measurements. The traceability of measurement results to stated references, and the development of Reference Measurement Systems (RMS), provide

The NISTmAb Reference Material 8671 Value Assignment, Homogeneity, and Stability

March 1, 2018
Author(s)
John E. Schiel, Abigail Turner, Catherine A. Mouchahoir, Katharina S. Yandrofski, Srivalli Telikepalli, Jason King, Paul C. DeRose, Dean C. Ripple, Karen W. Phinney
The NISTmAb Reference Material (RM) 8671 is intended to be the common industry standard monoclonal antibody for pre-competitive research in harmonizing current state-of-the-art technology and designing next generation characterization technologies for

Baseline Assessment of 25-Hydroxyvitamin D Assay Performance: A Vitamin D Standardization Program (VDSP) Interlaboratory Comparison Study

August 18, 2017
Author(s)
Christopher T. Sempos, Stephen Wise, Karen W. Phinney, Susan Tai, Johanna Camara, Gary L. Myers, Ramon Durazo-Arvizu, Lu Tian, John H. Eckfeldt, Andrew N. Hoofnagle, W. Greg Miller, Lorin M. Bachmann, Ian S. Young, J Pettit, G. Caldwell, A Liu, S P. Brooks, K. Sarafin, M. Thamm, C. Scheidt-Nave, G. B. Mensink, M. Busch, M. Rabenberg, Kevin Cashman, Mairead Kiely, Michael Kinsella, K Galvan, J. Y. Zhang, K OH, S. W. Lee, C. L. Jung, L. Cox, G. Goldberg, K. Guberg, S. Meadows, A. Prentice, G. Swan, A. Tedstone, Graham D. Carter, Julia C. Jones, P. Brannon, R. M. Lucas, P. M. Crump, Glenville Jones, E. Cavalier, Joyce Merkel, J. M. Betz
The Vitamin D Standardization Program (VDSP) coordinated an interlaboratory study to assess the comparability of measurements of total 25-hydroxyvitamin D [25(OH)D] in human serum, which is the primary marker of vitamin D status. A set of 50 individual

Baseline assessment of 25-hydroxyvitamin D reference material and proficiency testing/external quality assurance material commutability - a vitamin D standardization program study

August 10, 2017
Author(s)
Karen W. Phinney, Christopher T. Sempos, Hubert W. Vesper, Julianne C. Botelho, M Dasti, Yasamin Rahmani, Susan Tai, Johanna Camara, Stephen A. Wise, Gary L. Myers, Ramon Durazo-Arvizu, Lu Tian, John H. Eckfeldt, Andrew N. Hoofnagle, W. Greg Miller, Lorin M. Bachmann, Ian S. Young, J Pettit, G. Caldwell, A Liu, S P. Brooks, K. Sarafin, M. Thamm, C. Scheidt-Nave, G. B. Mensink, M. Busch, M. Rabenberg, Kevin Cashman, Mairead Kiely, Albert Flynn, Kirsten D. Dowling, B. Quinn, K OH, S. W. Lee, C. L. Jung, L. Cox, G. Goldberg, K. Guberg, S. Meadows, A. Prentice, G. Swan, Alison Tedstone, Schleicher Rosemary, Christine M. Pfeiffer, Graham D. Carter, Julia Jones, P. Brannon, R. M. Lucas, Neil C. Binkley, P. M. Crump, Donald Wiebe, Glenville Jones, J. M. Betz, C. D. Faigen, Joyce Merkel, Elizabeth A. Yetley, Paul M. Coates
The Vitamin D Standardization Program (VDSP) coordinated a study to assess the commutability of reference materials and proficiency testing/external quality assurance materials for total 25-hydroxyvitamin D [25(OH)D] in human serum, the primary indicator

General steps to standardize the laboratory measurement of serum total 25-hydroxyvitamin D

August 1, 2017
Author(s)
Karen W. Phinney, Christopher T. Sempos, J. M. Betz, Johanna Camara, Graham D. Carter, E. Cavalier, Michael W. Clarke, Kirsten D. Dowling, Ramon Durazo-Arvizu, Andrew N. Hoofnagle, A Liu, Kurtis Sarafin, Stephen A. Wise, Paul M. Coates
The Vitamin D Standardization Program (VDSP) has collaborated with numerous groups and agencies to assemble a set of tools, i.e. a reference measurement system, that can be used to establish traceability of 25-hydroxyvitamin D [25(OH)D] assays to relevant

Development of Standard Reference Material (SRM) 2973 Vitamin D Metabolites in Frozen Human Serum (High Level)

July 24, 2017
Author(s)
Susan Tai, Michael Nelson, Brian Lang, Karen W. Phinney, Lane C. Sander, James H. Yen, J. M. Betz, Christopher T. Sempos, Stephen Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health, Office of Dietary Supplements (NIH-ODS) and the Vitamin D Standardization Program (VDSP), has recently issued a new serum-matrix Standard

Value Assignment of Vitamin D Metabolites in Vitamin D Standardization Program (VDSP) Serum Samples

June 16, 2017
Author(s)
Karen W. Phinney, Johanna Camara, Susan Tai, Lane C. Sander, Stephen A. Wise, Linde A. De Grande, Linda M. Thienpont, Antonio M. Possolo, Blaza Toman, Christopher T. Sempos, J. M. Betz, Paul M. Coates
Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25(OH)D, value assignment of total 25(OH)D in 50 single donor

Development of an Improved Standard Reference Material for Vitamin D Metabolites in Human Serum

April 4, 2017
Author(s)
Karen W. Phinney, Susan S. Tai, Mary Bedner, Johanna Camara, Rosalind R. Chia, Lane C. Sander, Katherine E. Sharpless, Stephen A. Wise, James H. Yen, Rosemary L. Schleicher, Madhulika Chaudhary-Webb, Khin L. Maw, Yasamin Rahmani, Hubert W. Vesper, Joseph M. Betz, Joyce Merkel, Christopher T. Sempos, Paul M. Coates, Ramon Durazo-Arvizu, Kurtis Sarafin, Stephen P. Brooks

Mass Spectral Library Quality Assurance by Inter-Library Comparison

April 2, 2017
Author(s)
William E. Wallace, Weihua Ji, Dmitrii V. Tchekhovskoi, Karen W. Phinney, Stephen E. Stein
A method to discover and correct errors in mass spectral libraries is described. Comparing across a set of highly curated reference libraries compounds that have the same chemical structure quickly identifies entries that are outliers. In cases where three

A new approach to quantification of mAb aggregates using peptide affinity probes

February 10, 2017
Author(s)
Crystal Cheung, Kyle Anderson, Pooja Patel, Keale Cade, Karen W. Phinney, Illarion Turko
Using mAbs as therapeutic molecules is complicated by the propensity of mAbs to aggregate at elevated concentrations, which can lead to a variety of adverse events in treatment. Here, we describe a proof-of-concept for new methodology to detect and

Identification of novel N-glycosylation sites at non-canonical protein consensus motifs

June 14, 2016
Author(s)
Mark S. Lowenthal, Kiersta S. Davis, Lisa E. Kilpatrick, Catherine A. Mouchahoir, Karen W. Phinney
N-glycosylation is well known to occur at asparagine residues in the canonical consensus sequence N-X-S/T, but has also been identified at a small number of N-X-C motifs including the Asn491 residue of human serotransferrin. Here we report additional novel