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Search Publications by: Steven D. Hudson (Fed)

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Displaying 1 - 25 of 102

Two-fluid model for nonlinear flow of wormlike micelle solutions. I: Model

November 1, 2024
Author(s)
Paul Salipante, Michael Cromer, Steven D. Hudson
We develop a rheological model to approximate the nonlinear rheology of wormlike micelles using two constitutive models to represent a structural transition at high shear rates. The model is intended to describe the behavior of semidilute wormlike micellar

Two-fluid model for nonlinear flow of wormlike micelle solutions. II: Experiment

November 1, 2024
Author(s)
Paul Salipante, Michael Cromer, Steven D. Hudson
Applications often expose wormlike micelle solutions to a very wide range of shear and temperature conditions. The two-species model presented in Part I [Salipante et al., J. Rheol. 68 (2024)] describes the nonlinear rheology over a wide range of shear

Flow Activation Energy of High-Concentration Monoclonal Antibody Solutions and Protein-Protein Interactions Influenced by NaCl and Sucrose

August 20, 2024
Author(s)
Guangcui Yuan, Paul Salipante, Steven D. Hudson, Richard Gillilan, Qingqiu Huang, Harold Hatch, Vincent Shen, Alexander Grishaev, Suzette Pabit, Rahul Upadhya, Sudeep Adhikari, Jainik Panchal, Marco Blanco, Yun Liu
The solution viscosity and protein−protein interactions (PPIs) as a function of temperature (4−40 °C) were measured at a series of protein concentrations for a monoclonal antibody (mAb) with different formulation conditions, which include NaCl and sucrose

A small-volume microcapillary rheometer

March 30, 2022
Author(s)
Paul Salipante, Steve Kuei, Steven Hudson
We demonstrate a capillary device used to measure the shear rate dependent viscosity of microliter scale volumes. Liquid samples are driven pneumatically to fill a microcapillary and partially fill a larger glass capillary. The glass capillary is mounted

Blood vessel-on-a-chip examines biomechanics of microvasculature

November 15, 2021
Author(s)
Paul Salipante, Steven D. Hudson, Styliani Alimperti
We use a three-dimensional (3D) microvascular platform to measure the elasticity and membrane permeability of the endothelial cell layer. The microfluidic platform is connected with a pneumatic pressure controller to apply hydrostatic pressure. The

Spectroscopic and Spectrometric Approaches for Assessing the Composition of Embedded Metals in Tissues

November 24, 2020
Author(s)
Steven D. Hudson, Diane E. Smith, Todor Todorov, Adrian P. Defante, Jessica F. Hoffman, John F. Kalininch, Jose A. Centeno
Many medical devices contain metals that interface with the body. Additionally, embedded metal fragments from military wounds are typically not removed, to avoid the risk of morbidity associated with invasive surgery. The long-term health consequences of

Capillary RheoSANS: Measuring the Rheology and Nanostructure of Complex Fluids at High Shear Rates

July 15, 2020
Author(s)
Ryan P Murphy, Zachary W. Riedel, Marshall A. Nakatani, Paul Salipante, Javen S. Weston, Steven D. Hudson, Kathleen M Weigandt
Complex fluids containing micelles, proteins, polymers and inorganic nanoparticles are often processed and used in high shear environments that can lead to structural changes at the nanoscale. Here, capillary rheometery is combined with small-angle neutron

The impact of the metal interface on the stability and quality of a therapeutic fusion protein

January 9, 2020
Author(s)
Adrian P. Defante, Steven D. Hudson, Cavan K. Kalonia, Emma Keegan, Steven Bishop, Paul Santacroce, Satish Hasige
Subvisible particle formation which occurs after the sterile filtration step of the fill/finish process is challenge that may occur during the development of biotherapeutics with complex molecular structures. Here, we show that a stainless-steel pump head

Flow Resistance & Structures in Viscoelastic Channel Flows at Low Re

November 5, 2019
Author(s)
Boyang Qin, Paul Salipante, Steven Hudson, Paulo E. Arratia
The flow of viscoelastic fluids in channels and pipes remain poorly understood, particularly at low Reynolds numbers. Here, we investigate the flow of polymeric solutions in straight channels using pressure measurements and particle tracking. The law of

Upstream vortex and elastic wave in the viscoelastic flow around a confined cylinder

January 28, 2019
Author(s)
Boyang Qin, Paul Salipante, Steven Hudson, Paulo E. Arratia
The viscoelastic flow past cylinder is a classic benchmark problem that is not completely understood. Using novel holographic particle velocimetry, we report two main discoveries of the elastic instability upstream of a single cylinder in confined channel

Flow fluctuations in wormlike micelle fluids

October 22, 2018
Author(s)
Paul NMN Salipante, Steven Meek, Steven D Hudson
We investigate the unstable flow of wormlike micelle solutions in pressure driven capillary flow, with a focus on the effect of entrance geometry on the fluid fluctuations. The flow is measured at different points in the capillary using particle image

Simultaneous Slit Rheometry and In Situ Neutron Scattering

March 1, 2018
Author(s)
Javen Scott Weston, Daniel P. Seeman, Daniel L. Blair, Paul Salipante, Steven Hudson, Kathleen Weigandt
In situ measurement of fluid structure during flow, e.g., by neutron scattering, is key to understanding the relationship between structure and rheology. For some applications, structures at high shear rates heretofore unreachable are of particular

Protein Adsorption and Layer Formation at the Stainless Steel - Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody

February 9, 2018
Author(s)
Cavan K. Kalonia, Frank Heinrich, Joseph E. Curtis, Sid Raman, Maria A. Miller, Steven Hudson
Passage of specific protein solutions through certain pumps, tubing, and/or filling nozzles can result in the production of unwanted subvisible protein particles (SVP). In this work, surface mediated SVP formation was investigated. Specifically, the

Microparticle tracking velocimetry as a tool for microfluidic flow measurements

June 7, 2017
Author(s)
Paul NMN Salipante, Steven D Hudson, James W. Schmidt, John D. Wright
The accurate measurement of flows in microfluidic channels is important for commercial and research applications. We compare the accuracy of flow measurement techniques over a wide range flows. Flow measurements made using holographic microparticle

Jetting of a shear banding fluid in a rectangular duct

March 14, 2017
Author(s)
Paul NMN Salipante, Charles A. Little, Steven D Hudson
We report on a jetting flow instability of shear banding worm-like micelle (WLM) solutions in microfluidic channels with rectangular cross-sections over an intermediate volumetric flow regime. Particle tracking methods are used to measure the three

Complex Arrangement of Orthogonal Columns via a Supramolecular Orientational Memory Effect

November 22, 2016
Author(s)
Mihai Peterca, Mohammad Imam, Steven Hudson, Benjamin Partridge, D Sahoo, Paul A. Heiney, M L. Klein, Virgil Percec
Memory effects, including shape, chiral and liquid crystalline, enabled macroscopic materials with novel functions. However, the generation of complex supramolecular nanosystems via memory effects was not investigated. Here we report a cyclotriveratrylene

Jetting Flow of a Shear Banding Fluid

November 20, 2016
Author(s)
Paul NMN Salipante, Charles A. Little, Steven D Hudson
In this video we show the jetting behavior of a shear banding worm-like micelle solution in microfluidic flows. The jetting behavior is characterized by a self-contained portion of the channel where the flow velocity is greater than the surroundings. We

Reversible adsorption kinetics of near surface dimer colloids

August 2, 2016
Author(s)
Paul NMN Salipante, Steven D Hudson
We investigate the effect of shape on reversible adsorption kinetics using colloidal polystyrene dimers near a solid glass surface as a model system. The interaction between colloid and wall is tuned using electrostatic, depletion, and gravity forces to

Rheology of clustering protein solutions

July 5, 2016
Author(s)
Vishnu Dharmaraj, P. Douglas Godfrin, Yun Liu, Steven Hudson
High viscosity is a major challenge with protein therapeutics at extremely high concentration. Understanding the relationship between the concentration of a protein solution and its viscosity as a function of shear rate and temperature is therefore