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Search Publications by: Joseph Curtis (Fed)

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Displaying 26 - 50 of 90

Neutron Scattering in the Biological Sciences: Progress and Prospects

December 1, 2018
Author(s)
Rana Ashkar, Hassina Z. Bilheux, Heliosa Bordallo, Robert Briber, David J. E. Callaway, Xiaolin Cheng, Xiang-Qiang Chu, Joseph E. Curtis, Mark Dadmun, Paul Fenimore, David Fushman, Frank Gabel, Kushol Gupta, Frederick Herberle, Frank Heinrich, Liang Hong, John Katsaras, Zvi Kelman, Eugenia Kharlampieva, Gerald R. Kneller, Andrey Kovalevsky, Susan T. Krueger, Paul Langan, Raquel Lieberman, Yun Liu, Mathias Losche, Edward Lyman, Yimin NMN Mao, John Marino, Carla Mattos, Flora Meilleur, Peter Moody, Jonathan D. Nickels, William B. O'Dell, Hugh O'Neill, Ursula Perez-Salas, Judith Peters, Loukas Petridis, Alexei P. Sokolov, Robert Sutherland, Norman Wagner, Michael NMN Weinrich, Kevin Weiss, Troy Wymore, Yang Zhang, Jeremy C. Smith
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple scales of length and time. Pursuant to an NSF-funded workshop in February 2018, we review recent developments in this field as

Characterization of the NISTmAb Reference Material using Small-Angle Scattering and Molecular Simulation Part I: Dilute Protein Structures

March 1, 2018
Author(s)
Maria Monica Castellanos Mantilla, Steven C Howell, David T. Gallagher, Joseph E. Curtis
Both conformational and colloidal stability of therapeutic proteins must be closely monitored and thoroughly characterized to assess the long-term viability of drug products. In these series of papers on small-angle scattering, we characterize the IgG1

Protein Adsorption and Layer Formation at the Stainless Steel - Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody

February 9, 2018
Author(s)
Cavan K. Kalonia, Frank Heinrich, Joseph E. Curtis, Sid Raman, Maria A. Miller, Steven Hudson
Passage of specific protein solutions through certain pumps, tubing, and/or filling nozzles can result in the production of unwanted subvisible protein particles (SVP). In this work, surface mediated SVP formation was investigated. Specifically, the

Characterization of Monoclonal Antibody - Protein Antigen Complexes Using Small-Angle Scattering and Molecular Modeling

December 15, 2017
Author(s)
Maria Monica Castellanos Mantilla, James Anthony Snyder, Melody Lee, Srinivas Chakravarthy, Nicholas J. Clark, Arnold McAuley, Joseph E. Curtis
The determination of monoclonal antibody interactions with protein antigens in solution can lead to important insight to guide physical characterization and molecular engineering of therapeutic targets. We used small-angle scattering (SAS) combined with

Role of Molecular Flexibility and Colloidal Descriptions of Proteins in Crowded Environments from Small-Angle Scattering

November 10, 2016
Author(s)
Maria Monica Castellanos Mantilla, Nicholas J. Clark, Max C. Watson, Susan Krueger, Arnold McAuley, Joseph Curtis
Small-angle scattering is a powerful technique to study molecular conformation and interactions in a variety of systems. Recent work has questioned the validity of analyzing small-angle scattering data of protein solutions with models from the colloidal

Atomistic Modelling of Scattering Data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS) 1

October 17, 2016
Author(s)
Stephen J. Perkins, David W. Wright, Hailiang Zhang, Emre H. Brookes, Jianhan Chen, Thomas C. Irving, Susan T. Krueger, David J. Barlow, Karen J. Edler, David J. Scott, Nicholas J. Terrill, Stephen M. King, Paul Butler, Joseph E. Curtis
In solution scattering, the major investment worldwide in multiuser X-ray synchrotrons and neutron sources have resulted in huge advances in the throughput and accuracy of the experimental measurements. Whilst closed-source non-atomistic analytical

Monte Carlo Simulation Algorithm for B-DNA

September 27, 2016
Author(s)
Steven C Howell, Xiangyun Qiu, Joseph E. Curtis
The growing interest in determining structures of macromolecules containing deoxyribonucleic acid (DNA) in solution and their structure-function relationship has encouraged experiments using methods such as solution small angle X-ray and neutron scattering

Deuterium Labeling Together with Contrast Variation Small-Angle Neutron Scattering Suggests How Skp Captures and Releases Unfolded Outer Membrane Proteins

August 4, 2016
Author(s)
Nathan R. Zaccai, Clifford W. Sandlin, James T. Hoopes, Joseph E. Curtis, Patrick J. Fleming, Karen G. Fleming, Susan T. Krueger
In gram¿negative bacteria, the chaperone protein Skp forms specific and stable complexes with membrane proteins as these are transported across the periplasm to the outer membrane. The jellyfish¿like architecture of Skp is similar to the eukaryotic and

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties Among Polyubiquitins

March 1, 2016
Author(s)
Carlos A. Castaneda, Emma K. Dixon, Olivier Walker, Apurva Chaturvedi, Mark A. Nakasone, Joseph E. Curtis, Megan R. Reed, Susan T. Krueger, T. Ashton Cropp, David Fushman
Polyubiquitination, a critical protein post-translational modification, signals fora diverse set of cellular events via the different isopeptide linkages formed between the C0terminus of one ubiquitin (Ub) and the ε}-amine of K6, K11, K27, K29, K33, K48
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