U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Search Publications by: Yun Liu (Fed)

Search Title, Abstract, Conference, Citation, Keyword or Author
Displaying 126 - 150 of 185

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration

December 10, 2015
Author(s)
Gregory V. Barnett, Wei Qi, Samiul Amin, E. Neil Lewis, Vladimir I. Razinkov, Bruce A. Kerwin, Yun Liu, Christopher J. Roberts
Non-native protein aggregation may occur during manufacturing and storage of protein therapeutics, and this may decrease drug efficacy or jeopardize patient safety. From a regulatory perspective, changes in higher-order structure due to aggregation are of

Short-Time Glassy Dynamics in Viscous Protein Solutions with Competing Interactions

November 27, 2015
Author(s)
P. Douglas Godfrin, Steven Hudson, Kunlun Hong, Lionel Porcar, Peter Falus, Norman J. Wagner, Yun Liu
Although there have been numerous investigations of the glass transition for colloidal dispersions with only a short range attraction (SA), less is understood for systems interacting with a SA and an additional longer range repulsion (LR), which is

Direct Observation of Critical Adsorption on Colloidal Particles

August 25, 2015
Author(s)
Christopher E Bertrand, P. D. Godfrin, Yun Liu
Despite the fundamental role adsorbed solvent layers play in generating critical Casimir forces between colloidal particles, the structure of these layers has yet to be directly determined. Using small-angle neutron scattering ,we have measured critical

Molecular Dynamics of a Model Dimerizing Fluid

January 28, 2015
Author(s)
Christopher E Bertrand, Yun Liu
A model dimer forming fluid has been investigated by continuous molecular dynamics simulations. This study emphasizes the volume fraction and temperature dependence of the static and dynamic properties of the systems, including the structure factor, self

Kinetic Trapping of D 2 in MIL-53(AL) Observed using Neutron Scattering

July 14, 2014
Author(s)
Rachel Ann Pollock, Jae-Hyuk Her, Craig Brown, Yun Liu, Anne Dailly
We have studied gas adsorption effects on the structure of a metal organic framework, MIL-53(Al), a material well known due to the controllable framework 'breathing¿ phenomenon. Neutron powder diffraction between 4 K and 77 K and up to 4.5 bar pressure D 2

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

April 15, 2014
Author(s)
Eric J. Yearley, Paul D. Godfrin, Tatiana NMN Perevozchikova, Hailiang Zhang, Peter Falus, Lionel Porcar, Michihiro Nagao, Joseph E. Curtis, Pradad Gawande, Rosalynn Taing, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. Some concentrated mAb solutions are hypothesized to exhibit the formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is

Dynamical Arrest in Adhesive Hard-Sphere Dispersions Driven by Rigidity Percolation

December 6, 2013
Author(s)
Nestor E. Valadez-Perez, Yun Liu, Aaron P. R. Eberle, Norman J. Wagner, Ramon Castaneda-Priego
One major goal in condensed matter physics is identifying the physical mechanisms that lead to arrested states of matter, especially gels and glasses. The complex nature and microscopic details of each particular system are relevant. However, from both

Small-Angle Neutron Scattering Characterization of Monoclonal Antibody Conformations and Interactions at High Concentrations

August 6, 2013
Author(s)
Eric J. Yearley, Isidro E. Zarraga, Steven J. Shire, Thomas M. Scherer, Yatin Gokarn, Norman J. Wagner, Yun Liu
Small-angle neutron scattering (SANS) has been used to probe the solution structure of two protein therapeutics (MAb2 and MAb2) and their inter-protein potentials at high concentrations. These MAbs differ by small primary sequence variations in the