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Search Publications by: Elijah Petersen (Fed)

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Displaying 1 - 25 of 198

Trust Your Gut: Establishing Confidence in Gastrointestinal Models An Overview of the State of the Science and Contexts of Use

May 15, 2024
Author(s)
Susan Debad, David Allen, Maria Teresa Baltazar, Omari Bandele, Michaela Blaylock, Paul Brown, Maureen Bunger, Julia Co, Lynn Crosby, Amber Daniel, Steven Ferguson, Kevin Ford, Goncalo Gamboa da Costa, Kristin Gilchrist, Matthew Grogg, Maureen Gwinn, Thomas Hartung, Simon Hogan, Ye Jeong, George Kass, Elaina Kenyon, Nicole Kleinstreuer, Ville Kujala, Jaehyun Lim, Patrik Lundquist, Joanna Matheson, Shaun McCullough, Angela Melton-Celsa, Steven Musser, Ilung Oh, Oluwakemi Oyetade, Sarita Patil, Elijah Petersen, Nakissa Sadrieh, Christie Sayes, Benjamin Scruggs, Yu-Mei Tan, Bill Thelin, M. Tyler Nelson, Jose Tarazona, John Wambaugh, Jun-young Yang, Changwoo Yu, Suzanne Fitzpatrick
The webinar series and workshop titled Trust Your Gut: Establishing Confidence in Gastrointestinal Models–An Overview of the State of the Science and Contexts of Use was co-organized by NICEATM, NIEHS, FDA, EPA, CPSC, DoD, the Johns Hopkins Center for

Quantitative Evaluation of Released Nanomaterials from Carbon Nanotube Epoxy Nanocomposites during Environmental Exposure and Mechanical Treatment

September 29, 2023
Author(s)
Yue Zhao, David Goodwin, Lipiin Sung, Girish Ramakrishnan, Qiyuan Wu, Jiajie Cen, Elijah Petersen, Alexander Orlov
Carbon nanotubes (CNTs) are promising nanomaterials exhibiting high thermal and electrical conductivities, significant stiffness, high tensile strength, and light weight. As a result, CNTs have been utilized as additives to enhance properties of various

Federal perspective on critical research issues in nanoEHS

August 31, 2023
Author(s)
Janet Carter, Sri Nadadur, Rhema Bjorkland, William Boyes, Chuck Geraci, Vincent A. Hackley, John Howard, Alan Kennedy, Igor Linkov, Joanna Matheson, Holly Mortensen, Custudio Muinga, Elijah Petersen, Nora Savage, Stacey Standridge, Trey Thomas, Benjamin Trump
This article discusses critical issues and opportunities going forward in nanotechnology environmental, health, and safety (nanoEHS) research from the perspective of Federal Government agency participants in the U.S. National Nanotechnology Initiative (NNI

Orthogonal and complementary measurements of properties of drug products containing nanomaterials

January 6, 2023
Author(s)
Bryant C. Nelson, Elijah Petersen, Carl Simon Jr., Sven-Even Borgos, Luigi Calzolai, Jeremie Parot, Matthias Roesslein, Fanny Caputo, Xiaoming Xu
Quality control of pharmaceutical and biopharmaceutical products, and verification of their safety and efficacy, depends on reliable measurements of critical quality attributes (CQAs). The task becomes particularly challenging for drug products and

Potential artifacts and control experiments in toxicity tests of nanoplastic and microplastic particles

October 14, 2022
Author(s)
Elijah Petersen, Ana Barrios, Theodore Henry, Monique Johnson, Albert Koelmans, Antonio Montoro Bustos, Joanna Matheson, Matthias Roesslein, Jian Zhao, Baoshan Xing
To fully understand the potential ecological and human health risks from nanoplastics and microplastics (NMPs) in the environment, it is critical to make accurate measurements. Similar to past research on the toxicology of engineered nanomaterials, a broad

Technical Framework for High Quality New Approach Methodologies (NAMs)

July 15, 2022
Author(s)
Elijah Petersen, John T. Elliott, John Gordon, Nicole Kleinstreuer, Emily Reinke, Matthias Roesslein, Blaza Toman
New approach methodologies (NAMs) are in vitro, in chemico, and computational approaches that can potentially be used to reduce animal testing. For NAMs that require laboratory experiments, it is critical that they provide consistent and reliable results

Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies

June 2, 2022
Author(s)
Patricia Ceger, David Allen, Elyssa Arnold, Jennifer Brennan, Lyle Burgoon, Raanan Bloom, Carol Clarke, Natalia Garcia-Reyero, Kellie Fay, Jon Hamm, Paula Henry, Wesley Hunter, Donna Judkins, Nicole Kleinstreuer, Carlie Lalone, James Laurenson, Jessica Leet, Scott Lynn, Teresa Norberg-King, Edward Odenkirchen, Elijah Petersen, Barnett Rattner, Catherine Sprankle, Thomas Steeger, Jim Warren, Sarah Winfield
U.S. regulatory and research agencies utilize ecotoxicity test data to assess the hazards associated with substances that are released into the environment, including consumer products, industrial chemicals, metals and metalloids, nanomaterials, and

IVIVE: Facilitating the use of in vitro toxicity data in risk assessment and decision making

May 1, 2022
Author(s)
Xiaoqing Chang, Yu-Mei Tan, David Allen, Shannon Bell, Paul Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti Hakkinen, Shruti Kabadi, Nicole Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather Pangburn, Elijah Petersen, Emily Reinke, Alexandre Ribeiro, Nisha Sipes, Lisa Sweeney, John Wambaugh, Ronald Wange, Barbara Wetmore, Moiz Mumtaz
During the past few decades, the science of toxicology has been undergoing transformation from an observational to a predictive science. New approach methodologies (NAMs) including in vitro, in silico models, read across, and in vitro to in vivo

Current Nanomaterials Toxicity Testing Needs and Use of New Approach Methodologies Among Selected U.S. Federal Agencies

April 11, 2022
Author(s)
Elijah Petersen, Patricia Ceger, Jayme Coyle, David Allen, Raymond Derk, Natalia Garcia-Reyero, John Gordon, Nicole Kleinstreuer, Joanna Matheson, Danielle McShan, Bryant C. Nelson, Anil Patri, Liying Rojanasakul, Abhilash Sasidharan, Louis Scarano, Xiaoqing Chan
Engineered nanomaterials (ENMs) come in a wide array of shapes, sizes, surface coatings, and compositions, and often possess novel or enhanced properties compared to larger sized particles of the same elemental composition. To ensure the safe

Characteristics to Consider when Selecting a Positive Control Material for an In Vitro Assay

September 29, 2021
Author(s)
Elijah Petersen, Andrew Nguyen, Jeffrey Brown, John T. Elliott, Amy Clippinger, John Gordon, Nicole Kleinstreuer, Matthias Roesslein
The use of in vitro assays to inform decision-making requires robust and reproducible results across studies, laboratories, and time. Experiments using positive control materials are an integral component of an assay procedure to demonstrate the extent to