Publications

Displaying 1 - 25 of 88

In-line Thermal Desorption and Dielectric Barrier Discharge Ionization for Rapid Mass Spectrometry Detection of Explosives

August 5, 2024

Author(s)

Thomas P. Forbes, Liz Robinson, Edward Sisco, Abigail Koss

Thermal desorption (TD) of wipe-based samples was coupled with an in-line dielectric barrier discharge ionization (DBDI) source and rugged compact time-of-flight mass spectrometer (MS) for the detection of explosives, propellants, and post-blast debris

Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine

April 25, 2024

Author(s)

Thomas P. Forbes, J Greg Gillen, William Feeney, Johnny Ho

Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine. These capabilities are critical for narrow therapeutic index

Rapid chemical screening of microplastics and nanoplastics by thermal desorption and pyrolysis mass spectrometry with unsupervised fuzzy clustering

August 11, 2023

Author(s)

Thomas P. Forbes, John Pettibone, Eric S. Windsor, Joseph M. Conny, Robert A. Fletcher

The transport and chemical identification of microplastics and nanoplastics (MNPs) are critical to the concerns over plastic accumulation in the environment. Chemically and physically transient MNP species present unique challenges for isolation and

Field-Deployable Devices

January 1, 2023

Author(s)

Thomas P. Forbes, Raychelle Burks

Reductions in instrument size, weight, and power continue to facilitate the development and application of field-deployable devices for investigative purposes. Portable analytical instrumentation supporting the rapid and reliable identification of two

Unsupervised pharmaceutical polymorph identification and multicomponent particle mapping of ToF-SIMS data by non-negative matrix factorization

November 15, 2022

Author(s)

Thomas P. Forbes, J Greg Gillen, Amanda Souna, Jeffrey Lawrence

Crystal polymorphism of pharmaceutical compounds directly impacts resulting physicochemical characteristics, a critical aspect in active pharmaceutical ingredient (API) production. Tools to characterize and chemically map these polymorphs at the single

Detection and Analysis of Seed-Based Toxins using Direct Analysis in Real Time Mass Spectrometry (DART-MS) and its Variants

January 2, 2022

Author(s)

Edward Sisco, Natalie Damaso, Liz Robinson, James Robertson, Thomas P. Forbes

Detection of seed-based toxins is a need for forensic chemists when suspected poisonings occur. In these instances, seeds are often first mashed to extract the toxins, eliminating the ability to identify the seed, and therefore toxin, based on physical

Open port sampling interface mass spectrometry of wipe-based explosives, oxidizers, and narcotics for trace contraband detection

July 19, 2021

Author(s)

Thomas P. Forbes, Jeffrey Lawrence, Changtong Hao, J Greg Gillen

Rapid screening for chemical traces of explosives and narcotics is widely used to support homeland security and law enforcement. These target compounds span a range of physicochemical properties from organic to inorganic, with preferential ionization

Confined DART-MS for rapid chemical analysis of electronic cigarette aerosols and spiked drugs

June 29, 2021

Author(s)

Thomas P. Forbes, Shannon Krauss

A confined direct analysis in a real time mass spectrometry (DART-MS) system and method were developed for coupling directly with commercial electronic cigarettes for rapid analysis without sample preparation. The system consisted of a confining heated

Forensic Applications of DART-MS: A Review of Recent Literature

June 17, 2021

Author(s)

Edward Sisco, Thomas Forbes

The need for rapid chemical analyses and new analytical tools in forensic laboratories continues to grow due to case backlogs, difficult to analyze cases, and identification of previously unseen materials such as new psychoactive substances. To adapt to

DART-MS Spectral Similarity of Infrared Thermally Desorbed Solid Particulate and Solution Cast Propellant Samples

March 4, 2021

Author(s)

Thomas Forbes, John Gillen

Security and forensic applications employ test and reference materials to develop, calibrate, and validate analytical instrumentation such as mass spectrometry for the trace detection and chemical analysis of target analytes. An emerging class of target

Inorganic oxidizer detection from propellants, pyrotechnics, and homemade explosive powders using gradient elution moving boundary electrophoresis

February 1, 2021

Author(s)

Shannon T. Krauss, Thomas Forbes, Dillon Jobes

Advancement in rapid targeted chemical analysis of homemade and improvised explosive devices is critical for the identification of explosives-based hazards and threats. Gradient elution moving boundary electrophoresis (GEMBE), a robust electrokinetic

GRADIENT ELUTION MOVING BOUNDARY ELECTROPHORESIS OF HOMEMADE FUEL-OXIDIZER EXPLOSIVES

September 21, 2020

Author(s)

Thomas Forbes, Shannon T. Krauss, Dillion Jobes

The analysis of complex samples without extensive preparation steps (e.g., filtration or centrifugation) is a persistent challenge for applications ranging from forensic identification to high-throughput security screening. Here, a capillary-based

Trace Detection and Chemical Analysis of Homemade Fuel-Oxidizer Mixture Explosives: Emerging Challenges and Perspectives

September 4, 2020

Author(s)

Thomas Forbes, Shannon T. Krauss, John Gillen

The chemical analysis of homemade explosives (HMEs) and improvised explosive devices (IEDs) remains challenging for fieldable analytical instrumentation and sensors. Complex explosive fuel-oxidizer mixtures, black and smokeless powders, flash powders, and

Detection of fuel-oxidizer explosives utilizing portable capillary electrophoresis with wipe- based sampling

June 20, 2020

Author(s)

Shannon T. Krauss, Thomas Forbes, Jeffrey A. Lawrence, John G. Gillen, Jennifer R. Verkouteren

Portable analytical instrumentation that can provide an alarm indication for the presence of explosives and related components is critical for the identification of explosives‐based hazards and threats. Many explosives incident reports involve an inorganic

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