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Search Publications by: Edward Sisco (Fed)

Displaying 26 - 50 of 163

Spectral Trends in GC-EI-MS Data Obtained from the SWGDRUG Library and Literature: A Potential Resource for Identification of Unknown Compounds

October 24, 2022

Author(s)

William Feeney, Arun Moorthy, Edward Sisco

Rapid identification of new or emerging psychoactive substances remains a critical challenge in drug chemistry laboratories. Current analytical protocols are well designed for confirmation of known substances yet present struggles when potentially new

Rapid Emerging Drug Deployment Characterization Results: P2AP (RP0003)

October 1, 2022

Author(s)

Edward Sisco, Aaron Urbas

Algorithms and databases: unlocking non-targeted screening of small molecules with ambient ionization mass spectrometry

September 1, 2022

Author(s)

Edward Sisco

Nearly all sectors of analytical chemistry are finding applications for ambient ionization mass spectrometry (AI-MS) due to its ease of use, speed of analysis and sensitivity. While emphasis has been placed on developing new hardware to help analyze unique

Qualitative Analysis of Real Drug Evidence using DART-MS and the Inverted Library Search Algorithm

August 25, 2022

Author(s)

Edward Sisco, Meghan Appley, Stephen Tennyson, Arun Moorthy

Chromatographic-less mass spectrometry techniques like direct analysis in real time mass spectrometry (DART-MS) are steadily being employed as seized drug screening tools. However, these newer analytical platforms require new computational methods to best

Rapid GC-MS as a Screening Tool for Forensic Fire Debris Analysis

July 6, 2022

Author(s)

Briana Capistran, Edward Sisco

Techniques developed for the screening of forensic samples can be useful for increasing sample throughput and decreasing backlog in forensic laboratories. One such technique, rapid gas chromatography mass spectrometry (GC-MS), allows for fast sample

Updates to the Inverted Library Search Algorithm for Mixture Analysis

June 8, 2022

Author(s)

Arun Moorthy, Stephen Tennyson, Edward Sisco

Incorporating measurement variability when comparing sets of high-resolution mass spectra

May 5, 2022

Author(s)

Matthew Roberts, Arun Moorthy, Edward Sisco, Anthony J. Kearsley

Mass spectra are an important signature by which compounds can be identifi ed. We recently formulated a mathematical approach for incorporating measurement variability when comparing sets of high-resolution mass spectra. Leveraging replicate mass spectra

A Template for the Validation of DART-MS for Qualitative Seized Drugs Analysis

March 10, 2022

Author(s)

Edward Sisco, Amber Burns, Elizabeth Schneider, Laurel Bobka, Ikenna Ikpeama

Direct analysis in real time mass spectrometry (DART-MS) is an increasingly employed tool for a wide range of forensic applications including seized drug analysis. A significant body of research surrounds DART-MS for the analysis of seized drugs and how it

Development of an Open-Source Direct Analysis in Real Time Mass Spectrometry (DART-MS) Search Software and Library Building Tool for the Analysis of Complex Drug Mixtures

March 1, 2022

Author(s)

Edward Sisco, Arun Moorthy

Rapid Emerging Drug Deployment Characterization Results: N-Methyl-N-Isopropyltryptamine fumarate - 2

February 28, 2022

Author(s)

Edward Sisco, Aaron Urbas

Rapid Emerging Drug Deployment Characterization Results: POXP (RP0001)

February 28, 2022

Author(s)

Edward Sisco, Aaron Urbas

Rapid Emerging Drug Deployment Characterization Results: PTHP (RP0002)

February 28, 2022

Author(s)

Edward Sisco, Aaron Urbas

Detection and Analysis of Seed-Based Toxins using Direct Analysis in Real Time Mass Spectrometry (DART-MS) and its Variants

January 2, 2022

Author(s)

Edward Sisco, Natalie Damaso, Liz Robinson, James Robertson, Thomas P. Forbes

Detection of seed-based toxins is a need for forensic chemists when suspected poisonings occur. In these instances, seeds are often first mashed to extract the toxins, eliminating the ability to identify the seed, and therefore toxin, based on physical

Improving Particle Collection Efficiency of Sampling Wipes used for Trace Chemical Detection

December 31, 2021

Author(s)

J Greg Gillen, Jeffrey Lawrence, Edward Sisco, Matthew E. Staymates, Liz Robinson, Jennifer R. Verkouteren, Alexander Bulk

Improvement of the particle collection efficiency of sampling wipes is desirable for optimizing the performance of many wipe-based chemical analysis techniques used for trace chemical screening applications. In this note, commercially available Teflon