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Search Publications by: Charles Camp (Fed)

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Displaying 1 - 21 of 21

Coherent anti-Stokes Raman scattering (CARS) microscopy for polymers

April 1, 2022
Author(s)
Shuyu Xu, Charles Camp, Young Jong Lee
Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free chemical imaging modality capable of interrogating local molecular composition, concentration, and even orientation. In comparison to traditional Raman spectroscopy/imaging, CARS

Computational scanning tunneling microscope image database

December 5, 2021
Author(s)
Kamal Choudhary, Kevin Garrity, Charles Camp, Sergei Kalinin, Rama Vasudevan, Maxim Ziatdinov, Francesca Tavazza
We introduce the systematic database of scanning tunneling microscope (STM) images obtained using density functional theory (DFT) for two-dimensional (2D) materials, calculated using the Tersoff-Hamann method. It currently contains data for 716 exfoliable

Towards Absolute Viability Measurements for Bacteria

September 12, 2021
Author(s)
Joy Dunkers, Hariharan K. Iyer, Brynna H. Jones, Charles Camp, Stephan J. Stranick, Nancy Lin
Quantifying viable, vegetative bacteria is a critical measurand in healthcare diagnostics, food safety, and antimicrobial development. Viability determination has traditionally relied on such techniques as plate counting, colorimetric or fluorescent

Witnessing the survival of time-energy entanglement through biological tissue and media

June 9, 2021
Author(s)
Daniel J. Lum, Michael Mazurek, Alexander Mikhaylov, Kristen M. Parzuchowski, Ryan M. Wilson, Marcus Cicerone, Ralph Jimenez, Thomas Gerrits, Martin Stevens, Charles Camp
In this work, we demonstrate the preservation of time-energy entanglement of near-IR photons through thick biological media ( 1.55 mm) and tissue ( 235 um) at room temperature. Using a Franson-type interferometer, we demonstrate interferometric contrast of

pyMCR: A Python Library for Multivariate Curve Resolution Analysis

June 24, 2019
Author(s)
Charles H. Camp
In this work, a new software library is presented for performing multivariate curve resolution (MCR)analysis, a chemometric method for elucidating signatures of analytes ("endmember extraction") and their relative abundance (regression) from a series of

Broadband Coherent Anti-Stokes Raman Scattering

August 11, 2016
Author(s)
Charles H. Camp
Broadband coherent anti-Stokes Raman scattering (BCARS) microspectroscopy is a unique label-free imaging modality that provides detailed chemical information at each pixel. In minutes, this technique captures a “hyperspectral” cube that co-registers

Beam-Scanning for Rapid Coherent Raman Hyperspectral Imaging

December 14, 2015
Author(s)
Seungwan Ryu, Charles Camp, Ying Jin, Marcus T. Cicerone, Young Jong Lee
Coherent Raman imaging requires high peak power laser pulses to maximize the nonlinear multiphoton signal generation, but accompanying photo-induced sample damage often poses a challenge to microscopic imaging studies. We demonstrate that a beam-scanning

Chemically-Sensitive Bioimaging with Coherent Raman Scattering

April 29, 2015
Author(s)
Charles H. Camp, Marcus T. Cicerone
Raman scattering provides an intrinsic fingerprint of chemical composition. Spontaneous Raman spectroscopy has been used for many decades to interrogate biological materials and systems, but is not widely used for imaging due to relatively slow signal

High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues

July 20, 2014
Author(s)
Charles H. Camp, Young J. Lee, John M. Heddleston, Christopher M. Hartshorn, Angela R. Hight Walker, Jeremy N. Rich, Justin D. Lathia, Marcus T. Cicerone
We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique configuration of laser

Measuring Stem Cell Dimensionality in Tissue Scaffolds

April 1, 2014
Author(s)
Carl G. Simon Jr., Sapun Parekh, Christopher K. Tison, Girish Kumar, Tanya M. Farooque, Charles H. Camp
Many 3D scaffold systems have evolved for tissue engineering, drug screening and in vitro tissue models. However, it is not clear which scaffolds provide a 3D cell niche and there is no clear way to measure cell niche dimensionality. Advances in 3D niche

Multicomponent Chemical Imaging of Pharmaceutical Solid Dosage Forms with Broadband CARS Microscopy

July 15, 2013
Author(s)
Christopher M. Hartshorn, Marcus T. Cicerone, Young J. Lee, Charles H. Camp, John M. Heddleston, Patrick Marsac, Tim Rhodes, Zhen Liu, Nicole Canfield
We compare broadband coherent anti-Stokes Raman scattering (BCARS) microscopy with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingredient