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Search Publications by: Kevin Kiesler (Fed)

Displaying 26 - 34 of 34

A Strategy for Characterization of Single Nucleotide Polymorphisms in a Reference Material

September 25, 2015

Author(s)

Kevin M. Kiesler, Katherine Gettings, Peter Vallone

The advent and adoption of next generation sequencing (NGS) is enabling analysis of single nucleotide polymorphisms (SNPs) at an unprecedented scale, limited primarily by multiplexing during the PCR amplification based enrichment step used for forensic

The next dimension in STR sequencing: Polymorphisms in flanking regions and their allelic associations

September 24, 2015

Author(s)

Katherine Gettings, Rachel A. Aponte, Kevin M. Kiesler, Peter Vallone

Sequence data was analyzed from the flanking and repeat regions of 22 autosomal STR loci in 183 population samples. The flanking regions of the loci sequenced in this data set can be divided into six categories, based on the types of polymorphisms they

Performance of a next generation sequencing SNP assay on degraded DNA

May 27, 2015

Author(s)

Katherine Gettings, Kevin M. Kiesler, Peter Vallone

Forensic DNA casework samples are often of insufficient quantity or quality to generate full profiles by conventional DNA typing methods. Amplification of STR loci is inherently limited in samples containing degraded DNA, as the cumulative size of repeat

Comparison of Base Composition Analysis and Sanger Sequencing of Mitochondrial DNA for four U.S. Population Groups

October 8, 2013

Author(s)

Kevin M. Kiesler, Michael D. Coble, Thomas Hall, Peter Vallone

A set of 711 samples from four U.S. population groups was analyzed using a novel mass spectrometry based method for mitochondrial DNA (mtDNA) base composition profiling. Comparison of the mass spectrometry results with Sanger sequencing derived data

Allele frequencies for 40 autosomal SNP loci typed for US population samples using electrospray ionization mass spectrometry

May 20, 2013

Author(s)

Kevin M. Kiesler, Peter M. Vallone

Aim -- To type a set of 194 US African American, Caucasian,and Hispanic samples (self-declared ancestry) for 40 autosomal single nucleotide polymorphism (SNP) markers intended for human identification purposes. Methods -- Genotyping was performed on an