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Search Publications by: Elizabeth Kelley (Fed)

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Displaying 26 - 50 of 67

Collective Dynamics in Lipid Membranes Containing Transmembrane Peptides

June 21, 2021
Author(s)
Elizabeth Kelley, Paul Butler, Michihiro Nagao
Biological membranes are composed of complex mixtures of lipids and proteins that influence each other's structure and function. The biological activities of many channel-forming peptides and proteins are known to depend on the material properties of the

Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

April 7, 2021
Author(s)
Rahul Chadda, Nathan Bernhardt, Elizabeth Kelley, Susana Marujo Teixeira, Kacie Griffith, Alejandro Gil-Ley, Tugba Ozturk, Lauren Hughes, Ana Forsythe, Venkatramanan Krishnamani, Jose Faraldo-Gomez, Janice Robertson
Over two-thirds of integral membrane proteins of known structure assemble into oligomers. Yet, the forces that drive the association of these proteins remain to be delineated, as the lipid bilayer is a solvent environment that is both structurally and

Implementation of a Self-Consistent Slab Model of Bilayer Structure in the SasView Suite

February 1, 2021
Author(s)
Luoxi Tan, James G. Elkins, Brian H. Davison, Elizabeth Kelley, Jonathan Nickels
Slab models are simple and useful structural descriptions which have long been used to describe lyotropic lamellar phases, such as lipid bilayers. Typically, slab models break a bilayer structure into three pieces, an inner solvent-free core and two

Time-Resolved SANS Reveals Pore-Forming Peptides Cause Rapid Lipid Reorganization

January 15, 2021
Author(s)
Michael H. Nguyen, Mitchell DiPasquale, Brett W. Rickeard, Caesar G. Yip, Kaity N. Greco, Elizabeth Kelley, Drew Marquardt
Cells depend on proper lipid transport and their precise distribution for vital cellular function. Disruption of such lipid organization can be initiated by external agents to cause cell death. Here, we investigate two antimicrobial pore-forming peptides

Complex by Design: Hydrotrope-Induced Micellar Growth in Deep Eutectic Solvents

January 1, 2021
Author(s)
Adrian Sanchez-Fernandez, Anna E. Leung, Elizabeth Kelley, Andrew J. Jackson
Here the microstructure of hydrotrope-surfactant assemblies in 1:2 choline chloride:glycerol (ChCl:Glyc) is presented. The effect of choline salicylate (ChSal) on the micellization of hexadecyltrimethylammonium chloride (C 16TAC) was investigated by

Enhance Dynamics in the Anomalous Melting Regime of DMPG Lipid Membranes

October 16, 2020
Author(s)
Elizabeth Kelley, Michihiro Nagao, Paul Butler, Lionel Porcar, Bela Farago
Like many soft materials, lipids undergo a melting transition associated with a significant increase in their dynamics. At temperatures below the main melting transition (T m), all molecular and collective dynamics are suppressed, while above T m the alkyl

Scaling Relationships for the Elastic Moduli and Viscosity of Mixed Lipid Membranes

September 21, 2020
Author(s)
Elizabeth Kelley, Paul Butler, Rana Ashkar, Robert Bradbury, Michihiro Nagao
The elastic and viscous properties of biological membranes play a vital role in controlling cell functions that require local reorganization of the membrane components as well as dramatic shape changes such as endocytosis, vesicular trafficking, and cell

A Mechanical Mechanism for Vitamin E Acetate in E-cigarette/Vaping-Associated Lung Injury

August 26, 2020
Author(s)
Mitchell DiPasquale, Omotayo Gbadamosi, Michael H. L. Nguyen, Stuart R. Castillo, Brett W. Rickeard, Elizabeth Kelley, Michihiro Nagao, Drew Marquardt
The outbreak of electronic-cigarette/vaping associated lung injury (EVALI) has made thousands ill. This lung injury has been attributed to a physical interaction between toxicants from the vaping oils and the pulmonary surfactant. Pulmonary surfactant is

The Antioxidant Vitamin E as a Membrane Raft Modulator: Tocopherols do not Abolish Lipid Domains

August 1, 2020
Author(s)
Mitchell DiPasquale, Michael H. Nguyen, Brett W. Rickeard, Nicole Cesca, Christopher Tannous, Stuart R. Castillo, John Katsaras, Elizabeth Kelley, Frederick A. Heberle, Drew Marquardt
A great deal of individuals across North America regularly supplement their diet with the antioxidant, vitamin E. This billion-dollar supplementation industry encourages the use of vitamin E with little evidence supporting its actual health benefits

Color, Structure, and Rheology of a Diblock Bottlebrush Copolymer Solution

June 7, 2020
Author(s)
Matthew A. Wade, Dylan Walsh, Johnny Ching-Wei Lee, Elizabeth Kelley, Kathleen Weigandt, Damien Guironnet, Simon A. Rogers
A structure-property-process relation is established for a diblock bottlebrush copolymer solution, through a combination of rheo-neutron scattering, imaging, and rheological measurements. Polylactic acid-b-polystyrene diblock bottlebrush copolymers were

Interleaflet Coupling of n-Alkane Incorporated Bilayers

March 14, 2020
Author(s)
Hatsuho Usuda, Mafumi Hishida, Elizabeth Kelley, Yasuhisa Yamamura, Michihiro Nagao, Kazuya Saito
The relationship between the membrane bending modulus (k) and compressibility modulus (KA) depends on the extent of coupling between the two monolayers (leaflets). Using neutron spin echo (NSE) spectroscopy, we investigate the effects of n-alkanes on the

Transverse Lipid Organization Dictates Bending Fluctuations in Model Plasma Membranes

January 21, 2020
Author(s)
Brett W. Rickeard, Michael H. Nguyen, Mitchell DiPasquale, Caesar G. Yip, Hamilton Baker, Frederick A. Heberle, Xiaobing Zuo, Elizabeth Kelley, Michihiro Nagao, Drew Marquardt
Bending fluctuation is one of the most important dynamic modes of lipid membranes. These fluctuations play a vital role in many biological processes, most notoriously, contributing to the regulation of membrane protein activity. We investigated the bending

Clusters of Nanoscale Liposomes Modulate the Release of Encapsulated Species and Mimic the Compartmentalization Intrinsic in Cell Structures

October 23, 2019
Author(s)
Igor Kevin Mkam Tsengam, Marzhana Omarova, Lauren Shepherd, Nicholas Sandoval, Jibao He, Elizabeth Kelley, Vijay John
We report the ability to place a high concentration of liposomes in a confined volume as a multicompartment cluster that mimics biological cells and allows for the modulation of release of encapsulated species. The formation of these coated