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Search Publications by: Christopher Sims (Fed)

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Displaying 26 - 41 of 41

Controlled Potential Electrooxidation of Genomic DNA

January 11, 2018
Author(s)
Vytautas Reipa, Donald H. Atha, Sanem Hosbas Coskun, Christopher M. Sims, Bryant C. Nelson
Exposure of mammalian cells to oxidative stress can result in DNA damage that adversely affects many cell processes. We used bulk electrolysis in an electrochemical system and gas chromatographic mass spectrometric analysis (GC/MS/MS) to control and

Redox-active Nanomaterials for Nanomedicine Applications

October 6, 2017
Author(s)
Christopher Sims, Shannon Hanna, Daniel A. Heller, Christopher Horoszko, Monique Johnson, Antonio Montoro Bustos, Vytas Reipa, Kathryn Riley, Bryant C. Nelson
Nanomedicine utilizes the remarkable properties of nanomaterials for the diagnosis, treatment, and prevention of disease. Many of these nanomaterials have been shown to have robust antioxidative properties, potentially functioning as strong scavengers of

Quantitative Analysis of Oxidation State in Cerium Oxide Nanomaterials

May 14, 2017
Author(s)
Christopher Sims, Russell Maier, Aaron Johnston-Peck, Justin Gorham, Vincent A. Hackley, Bryant C. Nelson
Cerium oxide nanoparticles (nanoceria) are receiving increased attention from the research community due to the large number and wide range of their current and potential applications. The attractiveness of nanoceria for these various applications is

Biophysical Characterization of Functionalized Titania Nanoparticles and Their Application in Dental Adhesives

February 2, 2017
Author(s)
Jirun Sun, Elijah Petersen, Stephanie S. Watson, Christopher Sims, Alexander Kassman, Stanislav Frukhtbeyn, Drago Skrtic, Meryem T. Ok, Deborah Jacobs, Qiang Ye, Bryant C. Nelson
It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400-800 nm, 1600 mW/cm2) in comparison to nonfunctionalized TiO2 NPs

Separation, Sizing, and Quantitation of Engineered Nanoparticles in an Organism Model Using Inductively Coupled Plasma Mass Spectrometry and Image Analysis

December 16, 2016
Author(s)
Monique E. Johnson, Shannon Hanna, Antonio R. Montoro Bustos, Christopher M. Sims, Lindsay C. Elliott, Babak Nikoobakht, John T. Elliott, Richard D. Holbrook, Keana C. Scott, Karen E. Murphy, Elijah J. Petersen, Lee L. Yu, Bryant C. Nelson, Akshay Lingayat, Adrian C. Johnston
For environmental studies assessing uptake of orally ingested engineered nanoparticles (ENPs), a key step in ensuring accurate quantification of ingested ENPs is efficient separation of the organism from ENPs that are either nonspecifically adsorbed to the

Emerging Metrology for High Throughput Nanomaterial Genotoxicology

August 26, 2016
Author(s)
Bryant C. Nelson, Christa W. Wright, Yuko Ibuki, Maria Moreno-Villanueva, Hanna L. Karlsson, Giel Hendriks, Christopher M. Sims, Neenu Singh, Shareen H. Doak
The rapid development of the engineered nanomaterial (ENM) manufacturing industry has accelerated the incorporation of ENMs into a wide variety of consumer products across the globe. Unintentionally or not, some of these ENMs may be introduced into the

Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine

May 17, 2016
Author(s)
Bryant C. Nelson, Monique E. Johnson, Marlon L. Walker, Kathryn R. Riley, Christopher M. Sims
Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the