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Search Publications by: Natalia Kolmakova (Fed)

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CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity

June 15, 2020

Author(s)

Samantha Maragh, Natalia G. Kolmakova, Evgheni Strelcov

Current methods can illuminate the genome-wide activity of CRISPR–Cas9 nucleases, but are not easily scalable to the throughput needed to fully understand the principles that govern Cas9 specificity. Here we describe 'circularization for high-throughput