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Displaying 26 - 50 of 72

Microfluidic Directed Formation of Liposomes of Controlled Size

April 24, 2007
Author(s)
Andreas Jahn, Wyatt N. Vreeland, Don DeVoe, Laurie E. Locascio, Michael Gaitan
A new method to tailor liposome size and size distribution in a microfluidic format is presented. Liposomes are spherical structures formed from lipid bilayers that are from tens of nanometers to several micrometers in diameter. Liposome size and size

Microfluidic Method for Thermal Cycling by Microwave Dielectric Heating

November 9, 2006
Author(s)
Pierre-Alain Auroux, Jayna J. Shah, James Booth, Mulpuri Rao, Laurie E. Locascio, Michael Gaitan
We report on temperature time domain and spectral measurements for on-chip microwave thermocycling. In particular we observe enhanced specificity of the heating of a targeted sample compared to conventional heating block-based thermocyclers. Spatial

Photopatterned Polyelectrolyte Multilayers for Cell Culture

November 9, 2006
Author(s)
Darwin Reyes-Hernandez, J. Brian Hutchison, Laurie E. Locascio, Michael Gaitan
Patterned two-dimensional cell cultures are increasingly important for constructing bioanalytical tools for cell and molecular biology to address questions about interactions, signaling, migration, and differentiation, among others. This contribution

Polyelectrolyte Multilayers

January 23, 2006
Author(s)
Darwin Reyes-Hernandez, Laurie E. Locascio, Michael Gaitan
The process of self-assembly occurs naturally in living systems to form complex structures out of random events in an incredibly accurate way. Order out of disorder is achieved in a fashion that is analogous to a jigsaw puzzle where each piece fits

Liposomes As Model Cellular Systems

December 21, 2004
Author(s)
Laurie E. Locascio, Wyatt N. Vreeland, Andreas Jahn, Michael Gaitan
The discovery that phospholipids spontaneously form fluid-filled bubbles when exposed to aqueous solution was first made by Alec Bangham in the early 1960's while studying the effects of phospholipids on blood clotting in the Babraham Institute in England

Micropatterning Neuronal Cells on Polyelectrolyte Multilayers

July 7, 2004
Author(s)
Darwin Reyes-Hernandez, Elizabeth M. Perruccio, Patricia Becerra, Laurie E. Locascio, Michael Gaitan
This paper describes an approach to adhere retinal cells on micropatterned polyelectrolyte multilayer (PEM) lines adsorbed on polydimethylsiloxane (PDMS) surfaces, using microfluidic networks. PEMs were patterned on flat oxidized PDMS surfaces by