Majikes, J.
, Cho, S.
, Cleveland, T.
, Liddle, J.
and Balijepalli, A.
(2024),
Variable Gain DNA Nanostructure Charge Amplifiers for Biosensing, Nanoscale, [online], https://doi.org/10.1039/D4NR02959C, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=956471
(Accessed March 1, 2025)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Variable Gain DNA Nanostructure Charge Amplifiers for Biosensing
Published
Author(s)
, , , ,
Abstract
Electronic measurements of engineered nanostructures comprised solely of DNA (DNA nanostructures) enable new signal conditioning modalities in biosensing. Here, we demonstrate how these DNA nanostructures alter their conformation upon binding a nucleic acid analyte to drastically, and reversibly, amplify the measured electrochemical signal. This amplification was controlled by the applied electrical field to achieve a response ≈ 2×104 times greater than that measured from DNA hybridization. Because the amplification is independent of the interaction between the analyte and the DNA nanostructure, our approach provides a platform for tuning the response of the system for high performance that is agnostic of the end application. These molecularly precise self-assembled DNA nanostructures when paired with scalable electronic readout can therefore lead the way to highly sensitive multiplexed biosensing.Citation
Nanoscale
Volume
16
Issue
45
Pub Type
Journals
Download Paper
Keywords
DNA nanotechnology, cmos, DNA origami, bioelectronics
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.
Created December 7, 2024, Updated January 13, 2025