The field of glycomics defines the structures and functions of glycans, or sugars, in biological systems. Glycans perform many functions in cells and cell systems, from helping cells recognize invaders, to guiding cell growth, to enabling the folding of protein structures that affect health.
In support of the biomanufacturing and protein therapeutics communities, NIST research underpins the characterization of glycans in three focus areas:
This report describes the design of and results for the NIST Interlaboratory Study on the Glycosylation of NISTmAb, a Monoclonal Antibody Reference Material from 103 reports submitted by 76 laboratories. Two materials were used in the study, 1) the Primary Standard (PS) for NIST Reference Material 8671, NISTmAb, Humanized IgG1κ Monoclonal Antibody, and 2) a material derived from the PS by treatment with galactosidase.