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Bioscience & Health Programs & Projects

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Photodetector Analysis for Biological Agent Detection
Last Updated Date: 11/16/2012

Photomultiplier tube (PMT) analysis with respect to PMT sensitivity and long-term stability using synchrotron radiation.

Surface Characterization of Conjugated Gold Nanoparticles
Last Updated Date: 11/16/2012

This work examines the surface chemistry of conjugated gold nanoparticles, where the molecular modifiers are linked to the gold NP via a … more

Surface Plasmon Resonance Imaging of Cells and Extracellular Matrix Proteins
Last Updated Date: 10/10/2012

A critical challenge in cell biology is imaging and quantifying the interactions of cells with their extracellular matrix (ECM) environment, and … more

Automated Live Cell Imaging for Quantification of Catalytic Rates in Individual Cells
Last Updated Date: 10/10/2012

To accurately interpret the data from fluorescent proteins as reporters of gene activation within living cells, it is important to understand the … more

Improved Benchtop Connectivity to Complex Microfluidic Devices
Last Updated Date: 10/10/2012

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important … more

Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging
Last Updated Date: 10/10/2012

A collaboration between the Medical University of South Carolina (MUSC), Hollings Marine Laboratory, and NIST is examining the relationship … more

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity
Last Updated Date: 10/10/2012

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a … more

Cell-based Immunofluorescence Assays
Last Updated Date: 10/10/2012

Microscopy images of cells are often used in cell biology to qualitatively identify features of interest and to discern differences between … more

Multiparametric Measurement and Analysis of Cell Behavior on Extracellular Matrices
Last Updated Date: 10/10/2012

Cell responses to their culture environment always involve more than one component. An understanding of the relation between the physical and … more

26plex Autosomal Short Tandem Repeat Assay
Last Updated Date: 10/08/2012

A short tandem repeat (STR) multiplex assay was developed with 25 autosomal loci plus the sex-typing locus amelogenin for a total of 26 amplified … more

DNA Mixture Interpretation
Last Updated Date: 10/08/2012

Based on data collected over the last year from various forensic labs, (see http://www.cstl.nist.gov/biotech/strbase/mixture.htm ) the majority of … more

Rapid Multiplex PCR
Last Updated Date: 10/08/2012

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR … more

Rapid Measurement of Aggregation of Protein Therapeutics During Biomanufacturing
Last Updated Date: 10/05/2012

Protein therapeutics is the largest class of drugs made by the biotechnology industry. Aggregation of protein therapeutics is a major safety … more

Site-Specific Bioimaging
Last Updated Date: 10/02/2012

In collaboration with scientists at the Laboratory for Cell Biology (LCB) within the National Cancer Institute (NCI) of the National Institutes of … more

Next-Generation Metrology for Drug Delivery Systems
Last Updated Date: 10/02/2012

A critical metrology issue for pharmaceutical industries is the application of analytical techniques to the characterization of drug delivery … more

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