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Bioscience & Health Programs & Projects

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Cell-based Immunofluorescence Assays
Last Updated Date: 10/10/2012

Microscopy images of cells are often used in cell biology to qualitatively identify features of interest and to discern differences between … more

Multiparametric Measurement and Analysis of Cell Behavior on Extracellular Matrices
Last Updated Date: 10/10/2012

Cell responses to their culture environment always involve more than one component. An understanding of the relation between the physical and … more

Potential Primary Measurement Tool for the Quantification of DNA
Last Updated Date: 10/09/2012

The accurate mass determination of DNA and other nucleic acids is of critical importance in many clinical diagnoses and in forensic and molecular … more

Development of Reference Methods and Reference Materials for Proteins
Last Updated Date: 10/09/2012

A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For … more

26plex Autosomal Short Tandem Repeat Assay
Last Updated Date: 10/08/2012

A short tandem repeat (STR) multiplex assay was developed with 25 autosomal loci plus the sex-typing locus amelogenin for a total of 26 amplified … more

DNA Mixture Interpretation
Last Updated Date: 10/08/2012

Based on data collected over the last year from various forensic labs, (see http://www.cstl.nist.gov/biotech/strbase/mixture.htm ) the majority of … more

Rapid Multiplex PCR
Last Updated Date: 10/08/2012

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR … more

Rapid Measurement of Aggregation of Protein Therapeutics During Biomanufacturing
Last Updated Date: 10/05/2012

Protein therapeutics is the largest class of drugs made by the biotechnology industry. Aggregation of protein therapeutics is a major safety … more

Chemical Characterization of Nanomaterial Formulations for Cancer Treatment in Support of the NCI Nanotechnology Characterization Laboratory
Last Updated Date: 10/02/2012

New generations of nanoparticles are being developed to provide early-stage detection and treatment of cancer. Much of the evaluative work on … more

Environmental Leaching of Nanoparticles from Consumer Products
Last Updated Date: 10/02/2012

Nanoparticle-based consumer products are becoming available in the market at an increasing rate, but the safety of nanoparticles and the … more

Isotopes as Environmental Tracers in Archived Biological Specimens
Last Updated Date: 10/02/2012

There is increasing interest in the analytical and environmental communities in using mercury isotopic fingerprinting to identify source patterns … more

Methods and Measurements for Emerging Contaminants
Last Updated Date: 10/02/2012

Regulatory and health agencies within the US, Canada, and countries within Europe are continuously identifying compounds of suspected carcinogenic … more

Superresolving Optical Microscopy
Last Updated Date: 10/02/2012

Light microscopy is a widely used analytical tool because it provides non-destructive, real-time, three-dimensional imaging with chemical and … more

Site-Specific Bioimaging
Last Updated Date: 10/02/2012

In collaboration with scientists at the Laboratory for Cell Biology (LCB) within the National Cancer Institute (NCI) of the National Institutes of … more

Next-Generation Metrology for Drug Delivery Systems
Last Updated Date: 10/02/2012

A critical metrology issue for pharmaceutical industries is the application of analytical techniques to the characterization of drug delivery … more

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