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Bioscience

Projects/Programs

Keyword

Organizational Unit

Genome in a Bottle

Ongoing

Consortium hosted by NIST dedicated to authoritative characterization of benchmark human genomes. Sign up for General GIAB and Analysis Team email lists

Genome in a Bottle Workshops

Ongoing

Glycan Standard Reference Materials

Ongoing

HDX-MS for Biopharmaceutical Analysis

Ongoing

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

High-Precision Isotopic Reference Materials

Ongoing

Recent innovative advances in the design and manufacture of isotope ratio mass spectrometers (IRMS) have revolutionized the study of natural and man-induced

High-Sensitivity IR Spectroscopy of Proteins

Ongoing

New biological drugs such as peptide drugs, gene delivery cargos, and vaccines are emerging to fill pharmaceutical voids. Infrared (IR) absorption spectroscopy

Human Gut Microbiome Reference Material

Ongoing

To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need

Improved Benchtop Connectivity to Complex Microfluidic Devices

Ongoing

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important missing element in

Label-free imaging of cells and their extracellular matrix by SPR imaging

Ongoing

Large-Scale Genotype-Phenotype Landscape Measurements for Precision Engineering of Living Measurement Systems

Ongoing

All living things measure their environment, make decisions, and respond. Systematic re-engineering of these living measurement and control systems has the

Live Cell Imaging of Induced Pluripotent Stem Cell Populations

Ongoing

Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while

Living Yeast Cell Reference Material (RM 8230)

Ongoing

Confidence in total or viable microbial cell counting methods is lacking, due in part to a dearth of relevant reference materials. NIST has developed a living

Cryogenic electron microscopy (cryo-EM) image of an LNP/RNA formulation

LNP-RNA Research Grade Test Material

Ongoing

The National Institute of Standards and Technology (NIST) is currently engaged in an effort to produce a Research Grade Test Material (RGTM) consisting of

Magnetic Resonance Imaging (MRI) Biomarker Measurement Service

Ongoing

Provides services for SI-traceable calibrations of MRI-based biomarkers (such as proton relaxation times, water diffusion and tumor volume), in imaging

Magnetic Sensing and Metrology

Ongoing

The Magnetic Sensing and Metrology Program characterizes a wide variety of magnetic sensors used in biomedical, industrial, electronics, environmental

MML researchers develop reference materials and methods for quantitative phase microscopy with off-the-shelf products

Measurement Assurance for Quantitative Cell Imaging by Optical Microscopy

Ongoing

Measurement Techniques for Membranes and Membrane Proteins

Ongoing

Synthetic cell membrane constructs allow the simplification and complete control of a more complicated cellular system, as well as the incorporation of selected

S Mutans SEM image, in the process of forming complex networks.

Measurements for Microbial Ecology

Ongoing

Because of the complexity of microbial communities, we are working to develop measurements that will enable more reproducible design and control over of such

Measurements for minimal cells

Ongoing

Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a

Measurements of Point-Defect Chemistry in Complex Oxides

Ongoing

All inorganic materials contain point defects in the form of impurities, interstitials, or vacancies. Common imaging techniques fail to capture these defects

Measuring Antimicrobial Resistance

Ongoing

NIST is developing microbial measurements to better understand the propagation of antimicrobial resistance (AMR) through a variety of mechanisms. This work

Wordcloud figure with about 25 words including NIST, metabolomics, quality assurance, and measurements.

Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program

Ongoing

The NIST Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program has been created to demonstrate and improve the comparability of

Methods to determine the evolutionary stability of engineered biological function

Ongoing

Evolution poses unique challenges to engineering in living organisms. The successful implementation and development of a sustainable bioeconomy will require

Methods and Measurements of Nanoparticle Accumulation and Distribution in Organisms

Completed

Given the substantial differences between nanoparticles (NPs) and typical organic and inorganic environmental contaminants, new experimental methods and

Methods to Quantify Microbial Viability

Ongoing

Accurate measurement of microbial viability is crucial in infectious disease diagnosis and treatment; for development of microbial therapeutics, probiotics and

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---Fire Research Division
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---Computer Security Division
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---Applied and Computational Mathematics Division
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---Statistical Engineering Division
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---Software and Systems Division
----Systems Interoperability Group
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---Information Access Division
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---Standards Coordination Office
----International Standards Policy and Coordination Group
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---Special Programs Office
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---Office of Data and Informatics
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----Data Services Group
----Data Sciences Group
---Biosystems and Biomaterials Division
----Biomarker and Genomic Sciences Group
----Cellular Engineering Group
----Biomaterials Group
----Genome-Scale Measurements Group
----Complex Microbial Systems Group
----Cell Systems Science Group
----Biosystems and Biomaterials Division - HQ
---Chemical Sciences Division
----Biochemical and Exposure Science Group
----Chemical Informatics Group
----Optical Measurements Group
----Chemical Process and Nuclear Measurements Group
----Gas Sensing Metrology Group
----Inorganic Chemical Metrology Group
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----Chemical Sciences Division - HQ
----Marine Biochemical Sciences Group
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---Biomolecular Measurement Division
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----Biomolecular Measurement Division - HQ
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---Applied Chemicals and Materials Division
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---Materials Science and Engineering Division
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---Quantum Measurement Division
----Quantum Optics Group
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---Quantum Sensors Division
----Device Fabrication Group
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